Immobilization of NHC-Bearing Palladium Catalysts on Polyvinylpyridine; Applications in Suzuki-Miyaura and Hartwig-Buchwald Reactions under Batch and Continuous-Flow Conditions

Abstract

The facile coordinative immobilization of Organ’s PEPPSI^TM catalyst on a composite material composed of megaporous glass and polyvinylpyridine is described. The catalyst showed very good performance in Suzuki-Miyaura as well as Hartwig-Buchwald reactions of aryl chlorides under mild conditions and with low catalyst loadings. The modified PEPPSI^TM catalyst was probed both under batch mode and continuous-flow applications. The flow setup was also utilized to shed light on the stability of the PEPPSI^TM catalyst and the mobility of palladium.

microreactor - heterogeneous catalysis - Hartwig-Buchwald­ reaction - palladium - Suzuki-Miyaura reaction - immobilization

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