Immune cells of myeloid and lymphoid lineages constitute a significant cell mass in
the corpus luteum. Changes in the distribution and numbers of these cells within the
corpus luteum take place during the life span of the corpus luteum. These cells are
now recognized to be important both in structural changes of the corpus luteum as
well as in the regulation of steroidogenesis. Cytokines are secreted from immune cells
and other cells of the corpus luteum and comprise an important component of the intercellular
signaling that is regulating tissue remodeling and the endocrine activity of the gland.
This review covers recent findings of the participation of immune cells and cytokines
in the regulation of the corpus luteum function.
Corpus luteum - cytokine - leukocyte - luteinization - luteolysis
