Download PDF
Neuropediatrics 1991; 22(1): 36-42
DOI: 10.1055/s-2008-1071413
Original article

© Georg Thieme Verlag KG Stuttgart · New York

Combined Treatment Modality for Medulloblastoma in Childhood: Effects on Neuropsychological Functioning

D.  Riva1 , N.  Milani1 , C.  Pantaleoni1 , E.  Ballerini2 , C.  Giorgi3
  • 1Department Child Neurology, Ist. Neurologico "C. Besta", Via Celoria 11, I-20133 Milano
  • 2Department Pediatric Oncology, Ist. Nazionale dei Tumori, Milano
  • 3Department Neurosurgery, Ist. Neurologico "C. Besta"
Further Information

Publication History

Publication Date:
19 March 2008 (online)

  PDF Download  Permissions and Reprints

Abstract

8 long-surviving children, treated for medulloblastoma with combination radiotherapy and chemotherapy after surgery were examined in order to assess general intelligence, immediate attention and prolonged attention. Their siblings or first cousins were selected as controls.

The children with medulloblastoma performed significantly worse than their peers, both in intelligence tests and attention tests. A trend towards a positive correlation between age at the start of treatment and IQs was confirmed in our study, while there was no evidence of a correlation between IQs and time elapsed from therapy.

The role of chemotherapy, radiotherapy and their combination effect in producing neuropsychological sequelae is discussed.

Key words

Medulloblastoma - Radiotherapy - Chemotherapy - Intelligence - Attention

      >