Neuropediatrics 1993; 24(6): 319-323
DOI: 10.1055/s-2008-1071564
Original article

© Georg Thieme Verlag KG Stuttgart · New York

Moebius Syndrome: Continuous Tachypnea Verified by a Polygraphic Study

H.  Hamaguchi1 , T.  Hashimoto1 , K.  Mori1 , M.  Tayama1 , K.  Fukuda2 , S.  Endo2 , K.  Hiura3
  • 1Department of Pediatrics, School of Medicine, University of Tokushima, Japan
  • 2Department of Pediatrics, Kagawa Children's Hospital, Kagawa, Japan
  • 3Department of Pediatrics, Anan Kyoei Hospital, Tokushima, Japan
Further Information

Publication History

Publication Date:
19 March 2008 (online)

Abstract

Four polygraphic recordings were obtained in three cases of Moebius syndrome. The cases were a 4-month-old girl (Case 1), a 4-year-old boy (Case 2), and a 5-year-old girl (Case 3). The recordings revealed that in all three cases there was a lack of rapid eye movements to the lateral side, continuous low amplitude on chin EMG, and continuous tachypnea. In Case 3, polygrams were recorded at 2 and 5 years of age, both records showing the same pattern of tachypnea. Arterial blood gas analysis (AGA), PH, PaCO2 and PaO2 were found to be within normal limits. It has been assumed that this syndrome includes brainstem dysplasia, according to the chief symptoms, and autopsy and auditory brainstem response (ABR) findings. ABR examination showed low amplitudes of waves, a prolonged wave I-V interval, and the absence of wave V. It is known that there is a close relationship between this syndrome and respiratory disorders. But there have only been a few reports on respiratory disorders in this syndrome. It is strongly believed that continuous tachypnea is an important symptom of Moebius syndrome.

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