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Synfacts 2008(5): 0483-0483  
DOI: 10.1055/s-2008-1072639
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Catalytic Reformatsky Reaction

Contributor(s): Hisashi Yamamoto, Joshua P. Abell
M. Á. Fernández-Ibáñez, B. Maciá, A. J. Minnaard, B. L. Feringa*
University of Groningen, The Netherlands
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Publication History

Publication Date:
23 April 2008 (online)

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Significance

This paper describes the first example of an asymmetric catalytic Reformatsky reaction of aldehydes. Several groups have reported the successful application of other catalysts using ketones or imines but aldehydes remained difficult. The authors used a simple binol dialkyl zinc system.