Kardiologie up2date 2008; 4(3): 247-262
DOI: 10.1055/s-2008-1077626
Bildgebung und interventionelle Techniken

© Georg Thieme Verlag KG Stuttgart · New York

Prognosebeurteilung von KHK-Patienten: Die Rolle der Stressechokardiografie

Harald  Becher, Robert  Olszewski
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
29. Oktober 2008 (online)

Abstract

Stress-echocardiography und myocardial scintigraphy provide similar information on the prognosis of patients with and without heart disease. A normal stress echocardiogram does not exclude coronary stenoses but indicates a prognostically favourable outcome. Patients with a normal stress echocardiogram usually do not need further invasive assessment of coronary artery disease. There is an increasing risk of cardiac mortality and myocardial infarction depending on extent of abnormal findings during stress echocardiography. Stress echocardiography can be used to assess the short term prognosis of patients undergoing major non-cardiac surgery. The results of the stress echocardiogram identify those patients, in major surgery is of high risk. Newer echocardiographic technologies like Doppler tissue imaging, speckle tracking imaging and myocardial contrast echocardiography are promising, but still need to be validated in larger studies.

Kernaussagen

  • Stressechokardiografie und Myokardszintigrafie haben bezüglich der Prognose bei Patienten mit und ohne KHK eine ähnliche Aussagekraft.

  • Ein normales Stressechokardiogramm schließt Koronarstenosen nicht aus, spricht aber für eine gute Prognose. Die beste Prognose haben diejenigen Patienten, die ein normales Belastungs-Stressechokardiogramm haben.

  • Patienten mit einem normalen Belastungs-Stressechokardiogramm benötigen keine weitere Diagnostik, es sei denn, die klinische Symptomatik ändert sich. Auch Patienten mit einem normalen Dobutamin-Stressechokardiogramm benötigen in der Regel keine weitere Diagnostik, wenn kein Diabetes vorliegt.

  • Das kardiale Risiko steigt bei Frauen und Männern an, je mehr pathologische Befunde sich in der Stressechokardiografie finden. Auch bei Frauen erlaubt die Belastungs-Stressechokardiografie eine zuverlässige Aussage zum kardiovaskulären Risiko.

  • Die Stressechokardiografie erlaubt eine Aussage zur Prognose von Patienten, denen nicht kardiale chirurgische Eingriffe bevorstehen.

Literatur

  • 1 Fox K, Garcia M AA, Ardissino D. et al . Guidelines on the management of stable angina pectoris: executive summary: The Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology.  Eur Heart J. 2006;  27 1341-1381
  • 2 Senior R, Monaghan M, Becher H, Mayet J, Nihoyannopoulos P. British Society of Echocardiography . Stress echocardiography for the diagnosis and risk stratification of patients with suspected or known coronary artery disease: a critical appraisal. Supported by the British Society of Echocardiography.  Heart. 2005;  91 427-436
  • 3 Sicari R, Nihoyannopoulos P, Evangelista A. et al. on behalf of the European Association of Echocardiography . Stress echocardiography expert consensus statement.  Eur J Echocardiogr. 2008;  9 415-437
  • 4 Pellikka P A, Nagüh S F, Elhendy A A. et al . American Society of Echocardiography recommendations for performance, interpretation, and application of stress echocardiography.  JASE. 2007;  20 1021-1041
  • 5 Douglas P S, Khandheria B, Stainback R F. Stress Echocardiography Writing Group . ACCF/ASE/ACEP/AHA/ASNC/SCAI/SCCT/SCMR 2008 Appropriateness Criteria for Stress Echocardiography: A Report of the American College of Cardiology Foundation Appropriateness Criteria Task Force, American Society of Echocardiography, American College of Emergency Physicians, American Heart Association, American Society of Nuclear Cardiology, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, and Society for Cardiovascular Magnetic Resonance: Endorsed by the Heart Rhythm Society and the Society of Critical Care Medicine.  Circulation. 2008;  117 1478-1497
  • 6 Börsma E, Poldermans D, Bax J J. et al. for the DECREASE Study Group Predictors of Cardiac Events After Major Vascular Surgery . Role of Clinical Characteristics, Dobutamine Echocardiography, and beta-Blocker Therapy.  JAMA. 2001;  285 1865-1873
  • 7 Tsutsui J M, Elhendy A, Anderson J R. et al . Prognostic Value of Dobutamine Stress Myocardial Contrast Perfusion Echocardiography.  Circulation. 2005;  112 1444-1450
  • 8 Sicari R, Pasanisi E, Venneri L. et al . Stress echo results predict mortality: a large-scale multicenter prospective international study.  J Am Coll Cardiol. 2003;  41 589-595
  • 9 Marwick T H, Case C, Sawada S. et al . Prediction of mortality using dobutamine echocardiography.  J Am Coll Cardiol. 2001;  37 754-760
  • 10 Poldermans D, Fioretti P M, Börsma E. et al . Long-term prognostic value of dobutamine-atropine stress echocardiography in 1737 patients with known or suspected coronary artery disease: a single-center experience.  Circulation. 1999;  99 757-762
  • 11 Yao S S, Qureshi E, Sherrid M V, Chaudhry F A. Practical applications in stress echocardiography: risk stratification and prognosis in patients with known or suspected ischemic heart disease.  J Am Coll Cardiol. 2003;  42 1084-1090
  • 12 McCully R B, Roger V L, Mahoney D W. et al . Outcome after normal exercise echocardiography and predictors of subsequent cardiac events: follow-up of 1,325 patients.  J Am Coll Cardiol. 1998;  31 144-149
  • 13 Elhendy A, Mahoney D W, Khandheria B K. et al . Prognostic significance of the location of wall motion abnormalities during exercise echocardiography.  J Am Coll Cardiol. 2002;  40 1623-1629
  • 14 Marwick T H, Case C, Vasey C. et al . Prediction of mortality by exercise echocardiography. A strategy for combination with the Duke treadmill score.  Circulation. 2001;  29 2566-2571
  • 15 Metz L K, Beattie M, Hom R. et al . The prognostic value of normal exercise myocardial perfusion imaging and exercise echocardiography.  J Am Coll Cardiol. 2007;  49 227-237
  • 16 Marwick T H, Case C, Sawada S. et al . Prediction of mortality using dobutamine echocardiography.  J Am Coll Cardiol. 2001;  37 754-760
  • 17 Chaowalit N, McCully R B, Callahan M J. et al . Outcomes after normal dobutamine stress echocardiography and predictors of adverse events: long-term follow-up of 3014 patients.  Eur Heart J. 2006;  27 3039-3044
  • 18 Kamalesh M, Feigenbaum H, Sawada S. Assessing prognosis in patients with diabetes mellitus – the Achilles’ heel of cardiac stress imaging tests?.  Am J Cardiol. 2007;  99 1016
  • 19 Armstrong W F, Zoghbi W A. Stress Echocardiography: Current Methodology and Clinical Applications.  J Am Coll Cardiol. 2005;  45 1739-1747
  • 20 Biagini E, Elhendy A, Bax J J. et al . Seven-year follow-up after dobutamine stress echocardiography: impact of gender on prognosis.  J Am Coll Cardiol. 2005;  45 93-97
  • 21 Arruda-Olson A, Juracan E M, Mahoney D W. et al . Prognostic value of exercise echocardiography in 5,798 patients: is there a gender difference?.  J Am Coll Cardiol. 2002;  39 625-631
  • 22 Chaudhry F A, Qureshi E A, Yao S S, Bangalore S. Risk Stratification and Prognosis in Octogenarians Undergoing Stress Echocardiographic Study.  Echocardiography. 2007;  24 852-859
  • 23 Biagini E, Elhendy A, Schinkel A F. et al . Long-term prediction of mortality in elderly persons by dobutamine stress echocardiography.  J Gerontol A Biol Sci Med Sci. 2005;  60 1333-1338
  • 24 Bangalore S, Yao S S, Chaudhry F A. Usefulness of stress echocardiography for risk stratification and prognosis of patients with left ventricular hypertrophy.  Am J Cardiol. 2007;  100 536-543
  • 25 Marwick T H, Case C, Sawada S. et al . Use of stress echocardiography to predict mortality in patients with diabetes and known or suspected coronary artery disease.  Diabetes Care. 2002;  25 1042-1048
  • 26 Srivastava A V, Ananthasubramaniam K, Patel S J. et al . Prognostic implications of negative dobutamine stress echocardiography in African Americans compared to Caucasians.  Cardiovasc Ultrasound. 2008;  6 20
  • 27 Karagiannis S E, Feringa H H, Elhendy A. et al . Prognostic significance of renal function in patients undergoing dobutamine stress echocardiography.  Nephrol Dial Transplant. 2008;  23 601-607
  • 28 Lerakis S, Kalogeropoulos A P, El-Chami M F. et al . Transthoracic dobutamine stress echocardiography in patients undergoing bariatric surgery.  Obes Surg. 2007;  17 1475-1481
  • 29 Bangalore S, Yao S S, Chaudhry F A. Role of Right Ventricular Wall Motion Abnormalities in Risk Stratification and Prognosis of Patients Referred for Stress Echocardiography.  J Am Coll Cardiol. 2007;  50 1981-1989
  • 30 Bangalore S, Yao S S, Chaudhry F A. Role of Left Atrial Size in Risk Stratification and Prognosis of Patients Undergoing Stress Echocardiography.  J Am Coll Cardiol. 2007;  50 1254-1262
  • 31 Anselmi M, Pilati M, Golia G. et al . Ischemia Induced by Transesophageal Atrial Pacing Stress Echocardiography Predicts Long-Term Mortality.  Cardiology. 2008;  111 111-118
  • 32 Mastouri R, Mahenthiran J, Kamalesh M. et al . Prediction of ischemic events by anatomic M-mode strain rate stress echocardiography.  J Am Soc Echocardiogr. 2008;  21 299-306
  • 33 Ingul B C, Rozis E, Slordahl S A, Marwick T H. Incremental Value of Strain Rate Imaging to Wall Motion Analysis for Prediction of Outcome in Patients Undergoing Dobutamine Stress Echocardiography.  Circulation. 2007;  115 1252-1259
  • 34 Olszewski R, Timperley J, Szmigielski C. et al . The clinical applications of contrast echocardiography.  Eur J Echocardiogr. 2007;  8 S13-23
  • 35 Wake R, Takeuchi M, Yoshitani H. et al . Role of contrast-enhanced dobutamine stress echocardiography in predicting outcome in patients with known or suspected coronary artery disease.  Echocardiography. 2006;  23 642-649
  • 36 Yokoyama N, Schwarz K Q, Steinmetz S D. et al . Prognostic value of contrast stress echocardiography in patients with image quality too limited for traditional noncontrast harmonic echocardiography.  J Am Soc Echocardiogr. 2004;  17 15-20
  • 37 Tsutsui J M, Xie F, Cloutier D. et al . Real-time dobutamine stress myocardial perfusion echocardiography predicts outcome in the elderly.  Eur Heart J. 2008;  29 377-385

Harald Becher, MD PhD FRCP 

Consultant Cardiologist, Professor of Cardiac Ultrasound
University of Oxford
John Radcliffe Hospital
Cardiac Investigation Annexe

Headley Way
Oxford
OX3 9DU
United Kingdom

eMail: harald.becher@orh.nhs.uk

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