Formal Synthesis of Neopeltolide

V. V. Vintonyak; M. E. Maier

doi:10.1055/s-2008-1078528

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Synfacts 2008(8): 0791-0791
DOI: 10.1055/s-2008-1078528

Synthesis of Natural Products and Potential Drugs

Formal Synthesis of Neopeltolide

Contributor(s): Philip Kocienski, Indu Dager
V. V. Vintonyak, M. E. Maier*
Universität Tübingen, Germany

Further Information

Publication History

Publication Date:
23 July 2008 (online)

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Significance

Neopeltolide, a marine macrolide isolated from the sponge related to genus Daedalopelta sollas, inhibits the proliferation of adenocarcinoma, ovarian sarcoma and murine leukemia. The Prins cyclization to form the pyran ring in I features as the key step.