Enantioselective Suzuki Coupling of Unactivated Alkyl Halides

Significance

Nickel catalysts have been shown to be efficient promoters of the cross-coupling reactions of secondary halides. In this case, the authors have successfully expanded the nickel-catalyzed Suzuki coupling reaction to unactivated homobenzylic halides. In addition, the reactions are carried out in a highly enantioselective fashion under mild conditions. The main advantages of this methodology are broad substrate scope, clean conversion and the use of a commercial ligand that provides the products with high enantio­selectivity.