Abstract
Diabetes mellitus is a common disease among patients with pancreatic cancer and chronic
pancreatitis, disorders of the exocrine pancreas. Different clinical features of diabetes
are associated with these two conditions: hyperinsulinemia and peripheral insulin
resistance are the prevailing diabetic traits in pancreatic cancer, whereas reduced
islet cell mass and impaired insulin secretion are typically observed in chronic pancreatitis.
Whether or not a causal relationship exists between diabetes and pancreatic carcinoma
is an intriguing but unanswered question. Diabetes often precedes pancreatic cancer
and is thus regarded as a potential risk factor for malignancy. Conversely, pancreatic
cancer may secrete diabetogenic factors. Given these findings, there is increasing
interest in whether close monitoring of the glycemic profile may aid early detection
of pancreatic tumor lesions.
Key words
pancreatic cancer - chronic pancreatitis - diabetes mellitus
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Correspondence
Prof. Dr. M. SolimenaMD, PhD
Experimental Diabetology
Medical School Carl Gustav Carus
University of Technology Dresden
Fetscherstraße 74
01307 Dresden
Germany
Phone: +49/351/458 66 12
Fax: +49/351/458 63 30
Email: Michele.Solimena@tu-dresden.de
Correspondence
Prof. Dr. med. H. D. Saeger
Klinik und Poliklinik für Viszeral-, Thorax- und Gefäßchirurgie
Universitätsklinikum Carl Gustav Carus an der TU Dresden
Fetscherstraße 74
01307 Dresden
Germany
Phone: +49/351/458 27 42
Fax: +49/351/458 43 95
Email: Hans-Detlev.Saeger@uniklinikum-dresden.de
