Historical analysis of PAI-1 from its discovery to its potential role in cell motility and disease

Claudia Dellas; David J. Loskutoff

doi:10.1160/TH05-01-0033

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2005; 93(04): 631-640
DOI: 10.1160/TH05-01-0033

Theme Issue Article

Schattauer GmbH

Historical analysis of PAI-1 from its discovery to its potential role in cell motility and disease

Claudia Dellas

¹The Scripps Research Institute, Department of Cell Biology, Division of Vascular Biology, La Jolla, California, USA

,

David J. Loskutoff

¹The Scripps Research Institute, Department of Cell Biology, Division of Vascular Biology, La Jolla, California, USA

› Institutsangaben

Abstract

Summary

Although plasminogen activator inhibitor 1 (PAI-1) is one of the primary regulators of the fibrinolytic system, it also has dramatic effects on cell adhesion, detachment and migration. PAI-1 also differs from other serine protease inhibitors (serpins) in that it is a trace protein in plasma, it has a short half-life in vivo, its synthesis is highly regulated, and it binds to the adhesive glycoprotein vitronectin (VN) with high affinity and specificity. These unique and diverse properties of PAI-1 probably account for the many observations in the literature that correlate abnormalities in PAI-1 gene expression with a variety of pathological conditions. In this review, we discuss the discovery, origin, properties and regulation of PAI-1, and then speculate about its potential role in vascular disease, fibrosis, obesity and the metabolic syndrome, and cancer.

Keywords

PAI-1 - vascular disease - fibrosis - obesity - cancer

Volltext

Referenzen

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