Heparin and low-molecular-weight heparin

Elaine Gray; Barbara Mulloy; Trevor W. Barrowcliffe

doi:10.1160/TH08-01-0032

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2008; 99(05): 807-818
DOI: 10.1160/TH08-01-0032

Theme Issue Article

Schattauer GmbH

Heparin and low-molecular-weight heparin

Elaine Gray

¹National Institute for Biological Standards & Control, Potters Bar, UK

,

Barbara Mulloy

¹National Institute for Biological Standards & Control, Potters Bar, UK

,

Trevor W. Barrowcliffe

¹National Institute for Biological Standards & Control, Potters Bar, UK

²Current address: 3 Boulby Bank, Whitby, UK

› Author Affiliations

Abstract

Summary

Heparin is one of the oldest biological medicines, and has an established place in the prevention and treatment of venous thrombosis. Low-molecular-weight heparins (LMWH) have been developed by several manufacturers and have advantages in terms of pharmacokinetics and convenience of administration. They have been shown to be at least as effective and safe as unfractionated heparin and have replaced the latter in many indications. In this article the chemistry, mechanisms of action, measurement of anticoagulant activities, and clinical status of heparin and LMWH are reviewed.

Keywords

Heparin - low-molecular-weight heparin

Full Text

References

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