Platelet surface P-selectin expression is highly correlated with serotonin transporter density in human subjects

Pascal Frankhauser; Reka Baranyai; Thorben Ahrens; Patrick Schloss; Michael Deuschle; Florian Lederbogen

doi:10.1160/TH08-04-0227

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2008; 100(06): 1201-1203
DOI: 10.1160/TH08-04-0227

Letters to the Editor

Schattauer GmbH

Platelet surface P-selectin expression is highly correlated with serotonin transporter density in human subjects

Autoren

Pascal Frankhauser^*

¹Central Institute of Mental Health, Mannheim, Germany
Reka Baranyai^*

¹Central Institute of Mental Health, Mannheim, Germany

²Institute of Behavioural Sciences, Semmelweis University, Budapest, Hungary
Thorben Ahrens

¹Central Institute of Mental Health, Mannheim, Germany
Patrick Schloss

¹Central Institute of Mental Health, Mannheim, Germany
Michael Deuschle

¹Central Institute of Mental Health, Mannheim, Germany
Florian Lederbogen

¹Central Institute of Mental Health, Mannheim, Germany

Abstract

Volltext

Referenzen

References
1 McNicol A, Israels SJ. Platelet dense granules: structure, function and implications for haemostasis. Thromb Res 1999; 95: 1-18.
2 Dale GL, Friese P, Batar P. et al. Stimulated platelets use serotonin to enhance their retention of procoagulant proteins on the cell surface. Nature 2002; 415: 175-179.
3 Walther DJ, Peter JU, Winter S. et al. Serotonylation of small GTPases is a signal transduction pathway that triggers platelet alpha-granule release. Cell 2003; 115: 851-862.
4 Torres GE, Gainetdinov RR, Caron MG. Plasma membrane monoamine transporters: structure, regulation and function. Nat Rev Neurosci 2003; 04: 13-25.
5 Owens MJ, Nemeroff CB. Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clin Chem 1994; 40: 288-295.
6 American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: American Psychiatric Press; 1994
7 Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960; 23: 56-62.
8 Lederbogen F, Baranyai R, Gilles M. et al. Effect of mental and physical stress on platelet activation markers in depressed patients and healthy subjects: a pilot study. Psychiatry Res 2004; 127: 55-64.
9 Nash JF, Arora RC, Schreiber MA. et al. Effect of 3,4-methylenedioxymethamphetamine on [3H]paroxetine binding in the frontal cortex and blood platelets of rats. Biochem Pharmacol 1991; 41: 79-84.
10 Markwell MA, Haas SM, Bieber LL. et al. A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Anal Biochem 1978; 87: 206-210.
11 Schloss P, Betz H. Heterogeneity of antidepressant binding sites on the recombinant rat serotonin transporter SERT1. Biochemistry 1995; 34: 12590-12595.
12 McEver RP. Adhesive interactions of leukocytes, platelets, and the vessel wall during hemostasis and inflammation. Thromb Haemost 2001; 86: 746-756.
13 Larsen E, Celi A, Gilbert GE. et al. PADGEM protein: a receptor that mediates the interaction of activated platelets with neutrophils and monocytes. Cell 1989; 59: 305-312.
14 Koyama H, Maeno T, Fukumoto S. et al. Platelet P-selectin expression is associated with atherosclerotic wall thickness in carotid artery in humans. Circulation 2003; 108: 524-529.
15 Horschitz S, Hummerich R, Schloss P. Down-regulation of the rat serotonin transporter upon exposure to a selective serotonin reuptake inhibitor. Neuroreport 2001; 12: 2181-2184.
16 Carneiro AM, Blakely RD. Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter. J Biol Chem 2006; 281: 24769-24780.
17 Glatz K, Mossner R, Heils A. et al. Glucocorticoid-regulated human serotonin transporter (5-HTT) expression is modulated by the 5-HTT gene-promotor-linked polymorphic region. J Neurochem 2003; 86: 1072-1078.
18 Figueras G, Perez V, San Martino O. et al. Pretreatment platelet 5-HT concentration predicts the short-term response to paroxetine in major depression. Grupo de Trastornos Afectivos. Biol Psychiatry 1999; 46: 518-524.
19 Serebruany VL. Selective serotonin reuptake inhibitors and increased bleeding risk: are we missing something?. Am J Med 2006; 119: 113-116.
20 Glassman AH, Bigger JT, Gaffney M. et al. Onset of major depression associated with acute coronary syndromes: relationship of onset, major depressive disorder history, and episode severity to sertraline benefit. Arch Gen Psychiatry 2006; 63: 283-288.