Platelet function following trauma

Cristina Solomon; Stefan Traintinger; Bernhard Ziegler; Alexander Hanke; Niels Rahe-Meyer; Wolfgang Voelckel; Herbert Schöchl

doi:10.1160/TH11-03-0175

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2011; 106(02): 322-330
DOI: 10.1160/TH11-03-0175

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

Schattauer GmbH

Platelet function following trauma

A Multiple Electrode Aggregometry study

Authors

Cristina Solomon

¹Department of Anaesthesiology and Intensive Care Medicine, AUVA Trauma Centre, Salzburg, Austria

²Department of Anaesthesiology, Intensive Care and Perioperative Medicine, Salzburg University Hospital SALK, Salzburg, Austria
Stefan Traintinger

¹Department of Anaesthesiology and Intensive Care Medicine, AUVA Trauma Centre, Salzburg, Austria
Bernhard Ziegler

²Department of Anaesthesiology, Intensive Care and Perioperative Medicine, Salzburg University Hospital SALK, Salzburg, Austria
Alexander Hanke

³Department of Anaesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany
Niels Rahe-Meyer

³Department of Anaesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany

⁴Department of Anaesthesiology and Intensive Care Medicine, Franziskus Hospital, Bielefeld, Germany
Wolfgang Voelckel

¹Department of Anaesthesiology and Intensive Care Medicine, AUVA Trauma Centre, Salzburg, Austria
Herbert Schöchl

¹Department of Anaesthesiology and Intensive Care Medicine, AUVA Trauma Centre, Salzburg, Austria

⁵Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria

Abstract

Summary

Platelets play a central role in coagulation. Currently, information on platelet function following trauma is limited. We performed a retrospective analysis of patients admitted to the emergency room (ER) at the AUVA Trauma Centre, Salzburg, after sustaining traumatic injury. Immediately after admission to the ER, blood was drawn for blood cell counts, standard coagulation tests, and platelet function testing. Platelet function was assessed by multiplate electrode aggregometry (MEA) using adenosine diphosphate (ADPtest), collagen (COLtest) and thrombin receptor activating peptide-6 (TRAPtest) as activators. The thromboelastometric platelet component, measuring the contribution of platelets to the elasticity of the whole-blood clot, was assessed using the ROTEM^® device. The study included 163 patients, 79.7% were male, and the median age was 43 years. The median injury severity score was 18. Twenty patients (12.3%) died. Median platelet count was significantly lower among non-survivors than survivors (181,000/μl vs. 212,000/μl; p=0.01). Although platelet function defects were relatively minor, significant differences between survivors and non-survivors were observed in the ADPtest (94 vs. 79 U; p=0.0019), TRAPtest (136 vs. 115 U; p<0.0001), and platelet component (134 vs.103 MCE_EXTEM – MCE_FIBTEM; p=0.0012). Aggregometry values below the normal range for ADPtest and TRAPtest were significantly more frequent in non-survivors than in survivors (p=0.0017 and p=0.0002, respectively). Minor decreases in platelet function upon admission to the ER were a sign of coagulopathy accompanying increased mortality in patients with trauma. Further studies are warranted to confirm these results and investigate the role of platelet function in trauma haemostatic management.

Note: This work was carried out at the AUVA Trauma Centre, Salzburg, Austria.

Keywords

Acquired coagulation disorders - haemostasis - platelet pathology / inherited - acquired

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Referenzen

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