Haplotypes and haplotype-pairs of IL-1 beta and IL-6 genes and risk of non fatal myocardial infarction in the Western New York Acute MI Study

Monica de Gaetano; Gianni Quacquaruccio; Augusto Di Castelnuovo; Norma Nowak; Joan Dorn; Maria Benedetta Donati; Jo L. Freudenheim; Maurizio Trevisan; Licia Iacoviello

doi:10.1160/TH11-06-0377

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2011; 106(06): 1231-1233.
DOI: 10.1160/TH11-06-0377

Letters to the Editor

Schattauer GmbH

Haplotypes and haplotype-pairs of IL-1 beta and IL-6 genes and risk of non fatal myocardial infarction in the Western New York Acute MI Study

Monica de Gaetano^*

¹Laboratory of Genetic and Environmental Epidemiology, Research Laboratories, Fondazione di Ricerca e Cura “Giovanni Paolo II”, Catholic University, Campobasso, Italy

²School of Biomedical and Biomolecular Science, Conway Institute, University College Dublin, Ireland

,

Gianni Quacquaruccio^*

¹Laboratory of Genetic and Environmental Epidemiology, Research Laboratories, Fondazione di Ricerca e Cura “Giovanni Paolo II”, Catholic University, Campobasso, Italy

,

Augusto Di Castelnuovo

¹Laboratory of Genetic and Environmental Epidemiology, Research Laboratories, Fondazione di Ricerca e Cura “Giovanni Paolo II”, Catholic University, Campobasso, Italy

,

Norma Nowak

³Microarray and Genomics Facility, Roswell Park Cancer Institute, Buffalo New York, USA

⁴New York Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, Buffalo New York, USA

,

Joan Dorn

⁵Department of Social and Preventive Medicine, Buffalo University, Buffalo New York, USA

,

Maria Benedetta Donati

¹Laboratory of Genetic and Environmental Epidemiology, Research Laboratories, Fondazione di Ricerca e Cura “Giovanni Paolo II”, Catholic University, Campobasso, Italy

,

Jo L. Freudenheim

⁵Department of Social and Preventive Medicine, Buffalo University, Buffalo New York, USA

,

Maurizio Trevisan

⁶Health Sciences System, Nevada System of Higher Education, Las Vegas, Nevada, USA

,

Licia Iacoviello

⁶Health Sciences System, Nevada System of Higher Education, Las Vegas, Nevada, USA

› Author Affiliations

Abstract

Full Text

References

References
1 Iacoviello L, Di Castelnuovo A, Gattone M. et al. Polymorphisms of the interleukin-1beta gene and the risk of myocardial infarction and ischemic stroke at young age and the response of mononuclear cells to stimulation in vitro. Arterioscler Thromb Vasc Biol 2005; 25: 222-227.
2 Rogus J, Beck JD, Offenbacher S. et al. IL1B gene promoter haplotype pairs predict clinical levels of interleukin-1beta and C-reactive protein. Hum Genet 2008; 123: 387-398.
3 Latella MC, de Gaetano M, Di Castelnuovo A. et al. Interleukin 1 gene cluster, myocardial infarction at young age and inflammatory response of human mononuclear cells. Immunol Invest 2009; 38: 203-219.
4 Chen H, Wilkins LM, Aziz N. et al. Single nucleotide polymorphisms in the human interleukin-1B gene affect transcription according to haplotype context. Hum Mol Genet 2006; 15: 519-529.
5 McCann SE, Sempos C, Freudenheim JL. et al. Alcoholic beverage preference and characteristics of drinkers and nondrinkers in western New York (United States). Nutr Metab Cardiovasc Dis 2003; 13: 2-11.
6 Carlson CS, Eberle MA, Rieder MJ. et al. Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am J Hum Genet 2004; 74: 106-120.
7 Haplo.Stats. Available at: http://mayoresearch.mayo.edu/mayo/research/schaid_lab/upload/README.haplo.stats
8 Schaid DJ, Rowland CM, Tines DE. et al. Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am J Hum Gen 2002; 70: 425-434.
9 Lake SL, Lyon H, Tantisira K. et al. Estimation and tests of haplotype-enviroment interaction when linkage phase is ambiguous. Hum Hered 2003; 55: 56-65.
10 Eskin E, Halperin E, Karp RM. Efficient reconstruction of haplotype structure via perfect phylogeny. J Bioinform Comput Biol 2003; 1: 109-111.
11 Luotola K, Pietilä A, Zeller T. et al. Health 2000 and FINRISK97 Studies. Associations between interleukin-1 (IL-1) gene variations or IL-1 receptor antagonist levels and the development of type 2 diabetes. J Intern Med 2011; 269: 322-332.
12 Sims AM, Timms AE, Bruges-Armas J. et al. International Genetics of Ankylosing Spondylitis. Prospective meta-analysis of interleukin 1 gene complex polymorphisms confirms associations with ankylosing spondylitis. Ann Rheum Dis 2008; 67: 1305-1309.
13 El-Omar EM, Carrington M, Chow WH. et al. Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature 2000; 404: 398-402.
14 Gigante B, Bennet AM, Leander K. et al. The interaction between coagulation factor 2 receptor and interleukin 6 haplotypes increases the risk of myocardial infarction in men. PLoS One 2010; 5: e11300
15 Bis JC, Heckbert SR, Smith NL. et al. Variation in inflammation-related genes and risk of incident nonfatal myocardial infarction or ischemic stroke. Atherosclerosis 2008; 198: 166-173.
16 Kelberman D, Hawe E, Luong LA. et al. HIFMECH study group. Effect of Interleukin-6 promoter polymorphisms in survivors of myocardial infarction and matched controls in the North and South of Europe. The HIFMECH Study. Thromb Haemost 2004; 92: 1122-1128.
17 Maitra A, Shanker J, Dash D. et al. Polymorphisms in the IL6 gene in Asian Indian families with premature coronary artery disease--the Indian Atherosclerosis Research Study. Thromb Haemost 2008; 99: 944-950.