Disruption of components of vascular endothelial growth factor angiogenic signalling system in metabolic syndrome

Subrina Jesmin; Shamima Akter; Md. Mizanur Rahman; Md. Majedul Islam; A. M. Shahidul Islam; Sayeeda N. Sultana; Chishimba N. Mowa; Naoto Yamaguchi; Osamu Okazaki; Kawano Satoru; Sosuke Kimura; Michiaki Hiroe; Taro Mizutani; Masao Moroi

doi:10.1160/TH12-09-0654

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2013; 109(04): 696-705
DOI: 10.1160/TH12-09-0654

Endothelium and Vascular Development

Schattauer GmbH

Disruption of components of vascular endothelial growth factor angiogenic signalling system in metabolic syndrome

Findings from a study conducted in rural Bangladeshi women

Authors

Subrina Jesmin

¹Health & Disease Research Center for Rural Peoples (HDRCRP), Mohammadpur, Dhaka, Bangladesh

²Graduate School of Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan

³National Center for Global Health and Medicine (NCGM), Shinjuku-ku, Tokyo, Japan
Shamima Akter

¹Health & Disease Research Center for Rural Peoples (HDRCRP), Mohammadpur, Dhaka, Bangladesh

³National Center for Global Health and Medicine (NCGM), Shinjuku-ku, Tokyo, Japan
Md. Mizanur Rahman

⁴Department of Global Health Policy, University of Tokyo, Tokyo, Japan
Md. Majedul Islam

¹Health & Disease Research Center for Rural Peoples (HDRCRP), Mohammadpur, Dhaka, Bangladesh

³National Center for Global Health and Medicine (NCGM), Shinjuku-ku, Tokyo, Japan
A. M. Shahidul Islam

¹Health & Disease Research Center for Rural Peoples (HDRCRP), Mohammadpur, Dhaka, Bangladesh

³National Center for Global Health and Medicine (NCGM), Shinjuku-ku, Tokyo, Japan
Sayeeda N. Sultana

¹Health & Disease Research Center for Rural Peoples (HDRCRP), Mohammadpur, Dhaka, Bangladesh

³National Center for Global Health and Medicine (NCGM), Shinjuku-ku, Tokyo, Japan
Chishimba N. Mowa

¹Health & Disease Research Center for Rural Peoples (HDRCRP), Mohammadpur, Dhaka, Bangladesh
Naoto Yamaguchi

¹Health & Disease Research Center for Rural Peoples (HDRCRP), Mohammadpur, Dhaka, Bangladesh
Osamu Okazaki

³National Center for Global Health and Medicine (NCGM), Shinjuku-ku, Tokyo, Japan
Kawano Satoru

²Graduate School of Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
Sosuke Kimura

³National Center for Global Health and Medicine (NCGM), Shinjuku-ku, Tokyo, Japan
Michiaki Hiroe

³National Center for Global Health and Medicine (NCGM), Shinjuku-ku, Tokyo, Japan
Taro Mizutani

²Graduate School of Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
Masao Moroi

³National Center for Global Health and Medicine (NCGM), Shinjuku-ku, Tokyo, Japan

Abstract

Summary

Metabolic syndrome (MetS) is associated with impaired angiogenesis, a process that is chiefly regulated by vascular endothelial growth factor (VEGF) upon binding to its specific receptors, VEGF-R1 and VEGF-R2. The purpose of the present study was to assess trends or patterns in plasma levels of VEGF and its soluble receptors in subjects with (MetS) or without (non-MetS) MetS; and further examine their association with clinical or metabolic parameters using a subpopu-lation of South Asian country. A total of 1,802 rural Bangladeshi women aged ≥15 years were studied using a population-based cross-sectional survey. Plasma levels of VEGF were found to be significantly increased (MetS vs. non-MetS: 483.9 vs. 386.9, p<0.001), whereas, the soluble forms of VEGF receptors, sVEGF-R1 and sVEGF-R2, were significantly decreased in subjects with Mets (sVEGF-R1, MetS vs. non-MetS: 512.5 vs. 631.3, p<0.001; sVEGF-R2, MetS vs. non-MetS: 9,302.8 vs. 9,787.4, p=0.004). After adjustment for age and all potential variables, multiple regression analysis revealed that plasma levels of VEGF had significant positive association with blood glucose (p = 0.019) and body mass index (p = 0.007). We also found that mean plasma levels of VEGF increased in direct proportion to levels of MetS components. The present study is the first ever to demonstrate a positive association between trends in levels of plasma VEGF and MetS using a large sample size from South Asia. The association between plasma VEGF and MetS needs further investigations in order to clearly decipher the clinical predictive value and accuracy of plasma VEGF in MetS.

Keywords

Metabolic syndrome - vascular endothelial growth factor - rural Bangladeshi women - South Asian

Full Text

References

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