Abstract
Background Zofenopril is an antioxidant agent which has been shown to have beneficial effects
in hypertension and heart failure. The aim of this study was to test the effects of
Zofenopril on nerve regeneration and scarring in a rat model of peripheral nerve crush
injury.
Methods Twenty-one adult Sprague-Dawley rats underwent a surgical procedure involving right
sciatic nerve crush injury. 15 mg/kg Zofenopril was administered orally to seven rats
in group Z for seven days. Seven rats in group S received saline orally for seven
days. Seven rats in the control group C received no drug after crush injury. Fourteenth
and 42nd days after injury, functional and electromyography assessments of nerves
were performed. Functional recovery was analyzed using a walking track assessment,
and quantified using the sciatic functional index (SFI). After these evaluations,
all rats were sacrificed and microscopic evaluations were performed.
Results The Sciatic functional Index (SFI) in group Z on 14th day is different significantly from group S and group C (p = 0.037). But on 42nd day there was no difference between groups (p = 0.278). The statistical analyses
of electromyelographic (EMG) studies showed that the latency in group Z is significantly
different from group S (p = 0.006) and group C (p = 0.045). But on 42nd day there was no difference between groups like SFI (p = 0.147). The amplitude was
evaluated better in group Z than others (p < 0.05). In microscopic evaluation, we
observed the highest number of nerve regeneration in the group Z and the lowest in
the group C. But it was not significant statistically.
Conclusion Our results demonstrate that Zofenopril promotes the regeneration of peripheral nerve
injuries in rat models.
