IgA antiphospholipid syndrome – a rare clinical variant

Summary

IgA subtype antiphospholipid syndrome is a variant within the antiphospholipid syndrome group. It is also associated with a significantly increased risk of thrombembolic complications, as is the IgG antiphospholipid syndrome, IgM isotype. The clinical picture on the skin is varied, ranging from livedo race-mosa to ulcers cruris and disseminated vasculitic lesions. Especially the vasculitic changes can best be explained by the properties of the immunoglobulin subtype. The addition of IgA antibodies and a skin biopsy is often helpful for further diagnosis and differentiation of other differential diagnoses.

Keywords

Antiphospholipid syndrome - beta-2-glycoprotein IgA - vasculopathy - ulcus cruris

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