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CC BY 4.0 · Aorta (Stamford) 2015; 03(03): 108-117
DOI: 10.12945/j.aorta.2015.14.060
State-of-the-Art Review
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Dissecting the Dissection

Towards More Comprehensive Decision-Making Methodology for Thoracic Aortic Disease
Hisham M.F. Sherif
1   Department of Cardiac Surgery, Christiana Hospital, Christiana Care Health System, Newark, Delaware, USA
› Author Affiliations
Further Information

Publication History

30 September 2014

27 March 2015

Publication Date:
24 September 2018 (online)

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Abstract

Aortic dissection remains one of the most devastating diseases. Current practice guidelines provide diagnostic and therapeutic interventions based primarily on the aortic diameter. The level of evidence supporting these recommendations is Level C or “Expert Opinion” Since aortic dissection is a catastrophic structural failure, its investigation along the guidelines of accident investigation may offer a useful alternative, utilizing process mapping and root-cause analysis methodology. Since the objective of practice guidelines is to address the risk of serious events, on the utilization of a probabilistic predictive modeling methodology, using bioinformatics tools, may offer a more comprehensive risk assessment.

Key Words

Aortic - Dissection - Bioinformatics - Predictive modeling - Clinical guidelines
 

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