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Tierarztl Prax Ausg K Kleintiere Heimtiere 2014; 42(06): 374-382
DOI: 10.15654/TPK-140228
Originalartikel
Schattauer GmbH

Klassifikation der Bandscheibendegeneration des Hundes in der nativen Computertomographie und der Hochfeld-Magnetresonanztomographie

Classification of canine intervertebral disc degeneration using high-field magnetic resonance imaging and computed tomography
L. Harder
1   Klinik für Kleintiere, Stiftung Tierärztliche Hochschule Hannover
,
D. Ludwig
1   Klinik für Kleintiere, Stiftung Tierärztliche Hochschule Hannover
,
V. Galindo-Zamora
2   Klinik für Kleintiere, Nationaluniversität Kolumbien, Bogota
,
P. Wefstaedt
1   Klinik für Kleintiere, Stiftung Tierärztliche Hochschule Hannover
,
I. Nolte
1   Klinik für Kleintiere, Stiftung Tierärztliche Hochschule Hannover
› Author Affiliations
Further Information

Publication History

Eingegangen: 05 March 2014

Akzeptiert nach Revision: 01 June 2014

Publication Date:
08 January 2018 (online)

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Zusammenfassung

Gegenstand und Ziel: Die Klassifikation der kaninen Bandscheibendegeneration in der Magnetresonanztomographie ist in der Literatur beschrieben, während für die computertomographische Untersuchung kaniner Bandscheibenveränderungen bisher kein etabliertes Klassifikationssystem existiert. Da die Computertomographie ein häufig genutztes bildgebendes Verfahren in der Tiermedizin darstellt, war Ziel dieser Studie, ein derartiges Klassifikationssystems zu erstellen und zu validieren. Als vergleichende Methode stand eine T2-gewichtete magnetresonanztomographische Untersuchung zur Verfügung. Material und Methoden: Die computertomographische und magnetresonanztomographische Untersuchung von 43 Hunden ergab Bilddatensätze von 144 Bandscheiben. Diese Datensätze wurden verblindet, randomisiert und jeweils zweimal von drei Gutachtern beurteilt. Der Bewertung computertomographischer Datensätze lag das selbst entwickelte Klassifikationssystem zugrunde, während für die magnetresonanztomographischen Datensätze das Klassifikationssystem nach Pfirrmann angewendet wurde. Die Intra-und Interobserver-Übereinstimmung wurde mittels Statistical Analysis Software (SAS) bestimmt. Ergebnisse: Die Intra-und Interobserver-Übereinstimmung des Klassifikationssystems nach Pfirrmann (D-Werte 0,58–0,77) und des selbst entwickelten Klassifikationssystems (D-Werte 0,60–0,81) waren überwiegend gut. Zwischen den beiden Klassifikationssystemen ergab sich eine geringe Übereinstimmung (D = 0,26–0,29). Schlussfolgerung undklinische Relevanz: Eine zuverlässige Bewertung der Bandscheibendegeneration in der Computertomographie ist mit dem selbst entwickelten Klassifikationssystem möglich. Somit lassen sich zusätzliche Informationen für Diagnose und Prognose gewinnen. Die Computertomographie erfasst degenerative Veränderungen allerdings erst in einem fortgeschritteneren Stadium als die Magnetresonanztomographie.

Summary

Objective Although the classification of canine intervertebral disc degeneration using magnetic resonance imaging (MRI) has been described in the literature, there is no such classification using computed tomographic imaging. Because computed tomography (CT) is a frequently used diagnostic imaging tool in veterinary medicine, the aim of this study was the introduction and validation of such a scoring system. T2-weighted magnetic resonance images were available for comparative analysis. Material and methods: A total of 43 dogs were examined using CT and MRI. Image data records of 144 intervertebral discs were blinded, randomized and evaluated twice by three observers. CT data were analyzed using a self-developed scoring system, while MRI data sets were evaluated using the Pfirrmann scoring system. Intra-and interobserver agreement were determined using Statistical Analysis Software (SAS). Results Intra-and interobserver agreement were mostly substantial in the Pfirrmann (0.58–0.77) and self-developed (0.60–0.81) scoring systems. A slight agreement was found between both classification systems (D scores 0.26–0.29). Conclusion and clinical relevance: The self-developed scoring system allows a reliable assessment of canine intervertebral disc degeneration using CT imaging. Therefore, further diagnostic and prognostic information can be obtained. Degenerative changes in the intervertebral discs could be identified at an earlier stage when using MRI in comparison with CT.

Schlüsselwörter

Bandscheibenvorfall - Verkalkung - kanin - bildgebende Diagnostik - Klassifikationssystem

Key words

Intervertebral disc herniation - calcification - canine - diagnostic imaging - scoring system
 

  • Literatur

  • 1 Benneker LM, Heini PF, Anderson SE, Alini M, Ito K. Correlation of radiographic and MRI parameters to morphological and biochemical assessment of intervertebral disc degeneration. Eur Spine J 2005; 14 (01) 27-35.
    CrossrefPubMedGoogle Scholar
  • 2 Bergknut N, Auriemma E, Wijsman S, Voorhout G, Hagman R, Lagerstedt A. et al. Evaluation of intervertebral disk degeneration in chondrodystrophic and nonchondrodystrophic dogs by use of Pfirrmann grading of images obtained with low-field magnetic resonance imaging. Am J Vet Res 2011; 72 (07) 893-898.
    CrossrefPubMedGoogle Scholar
  • 3 Bergknut N, Egenvall A, Hagman R, Gustås P, Hazewinkel HAW, Meij BP, Lagerstedt A. Incidence of intervertebral disk degeneration-related diseases and associated mortality rates in dogs. J Am Vet Med Assoc 2012; 240 (11) 1300-1309.
    CrossrefPubMedGoogle Scholar
  • 4 Bergknut N, Grinwis G, Pickee E, Auriemma E, Lagerstedt A, Hagman R. et al. Reliability of macroscopic grading of intervertebral disk degeneration in dogs by use of the Thompson system and comparison with low-field magnetic resonance imaging findings. Am J Vet Res 2011; 72 (07) 899-904.
    CrossrefPubMedGoogle Scholar
  • 5 Bergknut N, Smolders LA, Grinwis GCM, Hagman R, Lagerstedt A, Hazewinkel HAW. et al. Intervertebral disc degeneration in the dog. Part 1: Anatomy and physiology of the intervertebral disc and characteristics of intervertebral disc degeneration. Vet J 2013; 195 (03) 282-291.
    PubMedGoogle Scholar
  • 6 Besalti O, Pekcan Z, Sirin YS, Erbas G. Magnetic resonance imaging findings in dogs with thoracolumbar intervertebral disk disease: 69 cases (1997–2005). J Am Vet Med Assoc 2006; 228 (06) 902-908.
    CrossrefPubMedGoogle Scholar
  • 7 Blumenkrantz G, Zuo J, Li X, Kornak J, Link TM, Majumdar S. In vivo 3.0-tesla magnetic resonance T1ρ and T2 relaxation mapping in subjects with intervertebral disc degeneration and clinical symptoms. Magn Reson Med 2010; 63 (05) 1193-1200.
    CrossrefPubMedGoogle Scholar
  • 8 Bray JP, Burbidge HM. The canine intervertebral disk: part one: structure and function. J Am Anim Hosp Assoc 1998; 34 (01) 55-63.
    CrossrefPubMedGoogle Scholar
  • 9 Fluehmann G, Doherr MG, Jaggy A. Canine neurological diseases in a referral hospital population between 1989 and 2000 in Switzerland. J Small Anim Pract 2006; 47 (10) 582-587.
    CrossrefPubMedGoogle Scholar
  • 10 Ford LT, Gilula LA, Murphy WA, Gado M. Analysis of gas in vacuum lumbar disc. Am J Roentgenol 1977; 128 (06) 1056-1057.
    CrossrefPubMedGoogle Scholar
  • 11 Hansen H. A pathologic-anatomical study on disc degeneration in dog, with special reference to the so-called enchondrosis intervertebralis. Acta Orthop Scand, Supplementum 1952; 11: 1.
    PubMedGoogle Scholar
  • 12 Israel SK, Levine JM, Kerwin SC, Levine GJ, Fosgate GT. The relative sensitivity of computed tomography and myelography for identification of thoracolumbar intervertebral disk herniations in dogs. Vet Radiol Ultrasound 2009; 50 (03) 247-252.
    CrossrefPubMedGoogle Scholar
  • 13 Jeffery ND, Levine JM, Olby NJ, Stein VM. Intervertebral disk degeneration in dogs: consequences, diagnosis, treatment, and future directions. J Vet Intern Med 2013; 27 (06) 1318-1333.
    CrossrefPubMedGoogle Scholar
  • 14 Jensen VF. Asymptomatic radiographic disappearance of calcified intervertebral disc material in the Dachshund. Vet Radiol Ultrasound 2001; 42 (02) 141-148.
    CrossrefPubMedGoogle Scholar
  • 15 Jensen VF, Arnbjerg J. Development of intervertebral disk calcification in the dachshund: a prospective longitudinal radiographic study. J Anim Hosp Assoc 2001; 37 (03) 274-282.
    PubMedGoogle Scholar
  • 16 Kalender W. General considerations on slice imaging. In: Computed tomography. Kalender W. ed. Erlangen: Publicis Corporate Pub; 2005: 18-31.
    Google Scholar
  • 17 Kettler A, Wilke H. Review of existing grading systems for cervical or lumbar disc and facet joint degeneration. Eur Spine J 2006; 15 (06) 705-718.
    CrossrefPubMedGoogle Scholar
  • 18 Kovacs FM, Royuela A, Jensen TS, Estremera A, Amengual G, Muriel A. et al. Agreement in the interpretation of magnetic resonance images of the lumbar spine. Acta Radiol 2009; 50 (05) 497-506.
    CrossrefPubMedGoogle Scholar
  • 19 Kuisma M, Karppinen J, Haapea M, Lammentausta E, Niinimäki J, Tervonen O. Modic changes in vertebral endplates: a comparison of MR imaging and multislice CT. Skeletal Radiol 2009; 38 (02) 141-147.
    CrossrefPubMedGoogle Scholar
  • 20 Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics 1977; 33 (01) 159-174.
    CrossrefPubMedGoogle Scholar
  • 21 Larde D, Mathieu D, Frija J, Gaston A, Vasile N. Spinal vacuum phenomenon: CT diagnosis and significance. J Comput Assist Tomogr 1982; 06 (04) 671-676.
    CrossrefPubMedGoogle Scholar
  • 22 Modic MT, Masaryk TJ, Ross JS, Carter JR. Imaging of degenerative disk disease. Radiology 1988; 168 (01) 177-186.
    CrossrefPubMedGoogle Scholar
  • 23 Müller MK, Ludewig E, Oechtering G, Scholz M, Flegel T. The vacuum phenomenon in intervertebral disc disease of dogs based on computed tomography images. J Small Anim Pract 2013; 54 (05) 253-257.
    CrossrefPubMedGoogle Scholar
  • 24 Olby NJ, Müntana KR, Sharp NJH, Thrall DE. The computed tomographic appearance of acute thoracolumbar intervertebral disc herniations in dogs. J Am Anim Hosp Assoc 2000; 41 (05) 396-402.
    PubMedGoogle Scholar
  • 25 Pearce RH, Thompson JP, Bebault GM, Flak B. Magnetic resonance imaging reflects the chemical changes of aging degeneration in the human intervertebral disk. J Rheumatol Suppl 1991; 27: 42-43.
    PubMedGoogle Scholar
  • 26 Pfirrmann CW, Metzdorf A, Zanetti M, Hodler J, Boos N. Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine 2001; 26 (17) 1873-1878.
    CrossrefPubMedGoogle Scholar
  • 27 Rodney S, Bagley RS, Gavin PR, Holmes SP. Diagnosis of spinal disease. In: Practical Small Animal MRI. Gavin PR, Bagley RS. eds. Ames, Iowa: Wiley Blackwell; 2009: 123-226.
    Google Scholar
  • 28 Rohdin C, Jeserevic J, Viitmaa R, Cizinauskas S. Prevalence of radiographic detectable intervertebral disc calcifications in Dachshunds surgically treated for disc extrusion. Acta Vet Scand 2010; 52 (01) 24.
    CrossrefPubMedGoogle Scholar
  • 29 Schmohl M. Bildgebende Verfahren zur Differenzierung von Veränderungen der Wirbelsäule. Vortragsband DVG-Vet-Congress. 6.–10.11.2013 in Berlin: 22-27.
    Google Scholar
  • 30 Schwarz T, Owen MR, Long S, Sullivan M. Vacuum disk and facet phenomenon in a dog with cauda equina syndrome. J Am Vet Med Assoc 2000; 217 (06) 862-864.
    CrossrefPubMedGoogle Scholar
  • 31 Seiler G, Häni H, Scheidegger J, Busato A, Lang J. Staging of lumbar intervertebral disc degeneration in nonchondrodystrophic dogs using low-field magnetic resonance imaging. Vet Radiol Ultrasound 2003; 44 (02) 179-184.
    CrossrefPubMedGoogle Scholar
  • 32 Smolders LA, Bergknut N, Grinwis G, Hagman R, Lagerstedt A, Hazewinkel HAW. et al. Intervertebral disc degeneration in the dog. Part 2: Chondrodystrophic and non-chondrodystrophic breeds. Vet J 2013; 195 (03) 292-299.
    PubMedGoogle Scholar
  • 33 Söffler C, Karpenstein H, Kramer M. Das intervertebrale Vakuumphänomen als computertomographischer Befund beim Hund und seine Bedeutung hinsichtlich operationswürdiger Bandscheibenvorfälle. Tierärztl Prax 2014; 42 (K): 88-93.
    PubMedGoogle Scholar
  • 34 Stigen O, Kolbjornsen O. Calcification of intervertebral discs in the dachshund: a radiographic and histopathologic study of 20 dogs. Acta Vet Scand 2007; 49 (01) 39.
    CrossrefPubMedGoogle Scholar
  • 35 Urban JP, Roberts S. Degeneration of the intervertebral disc. Arthritis Res Ther 2003; 05 (03) 120-138.
    PubMedGoogle Scholar