The relationship of syphilis to small vessel stroke in the absence of neurosyphilis: real or imaginary?

Cody L. Nathan; Joseph R. Berger

doi:10.1590/0004-282X-ANP-2021-E002

Arquivos de Neuro-Psiquiatria, Table of Contents

CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2021; 79(02): 101-102
DOI: 10.1590/0004-282X-ANP-2021-E002

Editorial

The relationship of syphilis to small vessel stroke in the absence of neurosyphilis: real or imaginary?

A relação da sífilis com o acidente vascular cerebral na ausência de neurossífilis: real ou imaginário?

Authors

Cody L. Nathan

¹University of Pennsylvania, Perelman School of Medicine, Department of Neurology, Philadelphia PA, USA.
Joseph R. Berger

¹University of Pennsylvania, Perelman School of Medicine, Department of Neurology, Philadelphia PA, USA.

Abstract

Full Text

References

References
1 Ferreira MG, Scavasine VC, Breda GL, Almeida BMM, Zérola VHF, Lange MC. Small vessel occlusion and syphilis in patients with first ever ischemic stroke. Arq Neuro-Psiquiatr. 2020. In Press.
2 Moore JE, Hopkins HH. Asymptomatic neurosyphilis. IV. The prognosis of early and late asymptomatic neurosyphilis. JAMA. 1930 Nov;95(22):1637-41. https://doi.org/10.1001/jama.1930.02720220007003
3 Hagihara M, Yamagishi Y, Kato H, Shibata Y, Shiota A, Sakanashi D, et al. Frequency of Treponema pallidum invasion into cerebrospinal fluid in primary or secondary early-stage syphilis. J Infect Chemother. 2018 May;24(5):404-6. https://doi.org/10.1016/j.jiac.2017.11.007
4 Clark EG, Danbolt N. The Oslo study of the natural history of untreated syphilis; an epidemiologic investigation based on a restudy of the Boeck-Bruusgaard material; a review and appraisal. J Chronic Dis. 1955 Sep;2(3):311-44. https://doi.org/10.1016/0021-9681(55)90139-9
5 Berger JR, Dean D. Neurosyphilis. Handb Clin Neurol. 2014;121:1461-72. https://doi.org/10.1016/B978-0-7020-4088-7.00098-5
6 Shi X, Wu J, Liu Z, Tang J, Su Y. Single photon emission CT perfusion imaging of cerebral blood flow of early syphilis patients. Chin Med J (Engl). 2003 Jul;116(7):1051-4.
7 Xiang L, Zhang T, Zhang B, Zhang C, Cui W, Yue W. Positive syphilis serology contributes to intracranial stenosis in ischemic stroke patients. Brain Behav. 2021 Jan;11(1):e01906. https://doi.org/10.1002/brb3.1906
8 Brightbill TC, Ihmeidan IH, Post MJ, Berger JR, Katz DA. Neurosyphilis in HIV-positive and HIV-negative patients: neuroimaging findings. AJNR Am J Neuroradiol. 1995 Apr;16(4):703-11.
9 Benjamin LA, Bryer A, Lucas S, Stanley A, Allain TJ, Joekes E, et al. Arterial ischemic stroke in HIV: Defining and classifying etiology for research studies. Neurol Neuroimmunol Neuroinflamm. 2016 Jun 30;3(4):e254. https://doi.org/10.1212/NXI.2021e0022021e0020254