Neurological complications in patients with SARS-CoV-2 infection: a systematic review

Renato Puppi MUNHOZ; José Luiz PEDROSO; Fábio Augusto NASCIMENTO; Sergio Monteiro de ALMEIDA; Orlando Graziani Povoas BARSOTTINI; Francisco Eduardo C CARDOSO; Hélio A Ghizoni TEIVE

doi:10.1590/0004-282X20200051

Arquivos de Neuro-Psiquiatria, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2020; 78(05): 290-300
DOI: 10.1590/0004-282X20200051

VIEW AND REVIEW

Neurological complications in patients with SARS-CoV-2 infection: a systematic review

Complicações neurológicas em pacientes infectados pelo SARS-CoV-2: uma revisão sistemática

Authors

Renato Puppi MUNHOZ

¹University of Toronto, Toronto Western Hospital, Movement Disorders Centre, Toronto ON, Canada.
José Luiz PEDROSO

²Universidade Federal de São Paulo, Escola Paulista de Medicina, Department of Neurology and Neurosurgery, São Paulo SP, Brazil.
Fábio Augusto NASCIMENTO

³Baylor College of Medicine, Department of Neurology, Houston TX, USA.
Sergio Monteiro de ALMEIDA

⁴Universidade Federal do Paraná, Hospital de Clínicas, Neuroinfection Outclinic, Virology Laboratory, Medical Pathology Department, Curitiba PR, Brazil.
Orlando Graziani Povoas BARSOTTINI

²Universidade Federal de São Paulo, Escola Paulista de Medicina, Department of Neurology and Neurosurgery, São Paulo SP, Brazil.
Francisco Eduardo C CARDOSO

⁵Universidade Federal de Minas Gerais, Hospital das Clínicas, Movement Disorders Unit, Neurology Service, Internal Medicine Department, Belo Horizonte MG, Brazil.
Hélio A Ghizoni TEIVE

⁶Universidade Federal do Paraná, Hospital de Clínicas, Internal Medicine Department, Neurology Service, Curitiba PR, Brazil.

Abstract

ABSTRACT

Background: As the COVID-19 pandemic unfolds worldwide, different forms of reports have described its neurologic manifestations. Objective: To review the literature on neurological complications of SARS-CoV-2 infection. Methods: Literature search performed following systematic reviews guidelines, using specific keywords based on the COVID-19 neurological complications described up to May 10^th, 2020. Results: A total of 43 articles were selected, including data ranging from common, non-specific symptoms, such as hyposmia and myalgia, to more complex and life-threatening conditions, such as cerebrovascular diseases, encephalopathies, and Guillain-Barré syndrome. Conclusion: Recognition of neurological manifestations of SARS-CoV-2 should be emphasized despite the obvious challenges faced by clinicians caring for critical patients who are often sedated and presenting other concurrent systemic complications.

RESUMO

Introdução: À medida que a pandemia da COVID-19 se desenvolve em todo o mundo, diferentes tipos de publicações descreveram suas manifestações neurológicas. Objetivo: Revisar a literatura sobre complicações neurológicas da infecção por SARS-CoV-2. Métodos: A pesquisa bibliográfica foi realizada seguindo diretrizes de revisões sistemáticas, usando palavras-chave específicas baseadas nas complicações neurológicas da COVID-19 descritas até 10 de maio de 2020. Resultados: Foram selecionados 43 artigos, incluindo descrições que variam de sintomas comuns e inespecíficos, como hiposmia e mialgia, a condições mais complexas e com risco de vida, como doenças cerebrovasculares, encefalopatias e síndrome de Guillain-Barré. Conclusão: O reconhecimento das manifestações neurológicas da SARS-CoV-2 deve ser enfatizado apesar dos óbvios desafios enfrentados pelos clínicos que cuidam de pacientes críticos, muitas vezes sedados e apresentando outras complicações sistêmicas concomitantes.

Keywords:

Coronavirus Infections - COVID-19 - Neurology - Guillain-Barré Syndrome - Encephalitis - Stroke

Palavras-chave:

Infecções por Coronavírus - COVID-19 - Neurologia - Síndrome de Guillain-Barré - Encefalopatias - Acidente Vascular Cerebral - Mialgia

Volltext

Referenzen

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