Streptococcus pneumoniae serotype 6C in Costa Rican children with otitis media before introduction of the 7-valent pneumococcal conjugated vaccine into the national immunization program

Arturo Abdelnour; Carolina Soley; Silvia Guevara; Nurith Porat; Ron Dagan; Adriano Arguedas

doi:10.3233/JPI-2012-0331

Journal of Pediatric Infectious Diseases, Table of Contents

J Pediatr Infect Dis 2011; 06(04): 243-246
DOI: 10.3233/JPI-2012-0331

Georg Thieme Verlag KG Stuttgart – New York

Streptococcus pneumoniae serotype 6C in Costa Rican children with otitis media before introduction of the 7-valent pneumococcal conjugated vaccine into the national immunization program

Authors

Arturo Abdelnour

^aInstituto de Atención Pediátrica, San José, Costa Rica
Carolina Soley

^aInstituto de Atención Pediátrica, San José, Costa Rica

^bUniversidad de Ciencias Médicas San José, Costa Rica
Silvia Guevara

^aInstituto de Atención Pediátrica, San José, Costa Rica
Nurith Porat

^cPediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Ron Dagan

^cPediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Adriano Arguedas

^aInstituto de Atención Pediátrica, San José, Costa Rica

^bUniversidad de Ciencias Médicas San José, Costa Rica

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Abstract

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Abstract

During the years 1999 through 2008 middle ear fluid (MEF) and nasopharyngeal/oropharyngeal (NP/OP) samples were obtained from Costa Rican children with otitis media (OM). Streptococcus pneumoniae was identified and serotyped according to standard procedures. A total of 1,389 MEF isolates were collected, of which 353 (25%) were S. pneumoniae. Serotyping was performed in 286/353 (81%) isolates, of which 40 (14%) were serogroup 6: serotype 6A (10/40; 25%), 6B (27/40; 67%) and 6C (3/40; 8%). Among 755 NP/OP S. pneumoniae isolated, 537 (71%) were serotyped and serogroup 6 was identified in 112 (21%) isolates: 6A (24/112; 21%), 6B (78/112; 70%), and 6C (10/112; 9%). Twenty percent, 86% and 0% of serotypes 6A, 6B and 6C isolated from the MEF, respectively, were penicillin non-susceptible (MIC ≥ 0.06 μg/mL) and among the NP/OP isolates, 25%, 17.9% and 10%, respectively, were penicillin non-susceptible. Our results show that in Costa Rican children with OM, S. pneumoniae serotype 6C is an infrequent cause of OM and is sporadically found in NP/OP samples.

Keywords

Streptococcus pneumoniae - serotypes - otitis media - vaccines

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