Journal of Pediatric Neurology 2013; 11(02): 115-117
DOI: 10.3233/JPN-130606
Case Report
Georg Thieme Verlag KG Stuttgart – New York

Human parechovirus causing extensive white matter brain injury in a neonate

Vinay M. Shivamurthy
a   Department of Pediatric Neurology, Leicester Royal Infirmary, Leicester, UK
,
N. Nandhakumar
b   Department of Pediatrics, Kettering General Hospital, Northamptonshire, UK
,
Jayaprakash A. Gosalalakkal
a   Department of Pediatric Neurology, Leicester Royal Infirmary, Leicester, UK
,
Nahin Hussain
a   Department of Pediatric Neurology, Leicester Royal Infirmary, Leicester, UK
› Author Affiliations

Subject Editor:
Further Information

Publication History

08 October 2010

09 August 2012

Publication Date:
30 July 2015 (online)

Abstract

There is a wide differential for white matter changes on magnetic resonance imaging in an un-well neonate. Human parechovirus is one of the very few neurotropic viruses, which presents with sepsis like illness or encephalitis in neonates and can cause extensive white matter changes in the brain. We present a 7-week-old infant with fever, lethargy and poor feeding, who had extensive white matter changes on magnetic resonance imaging of the brain. Cerebrospinal fluid polymerase chain reaction was positive for human parechovirus.