Abstract
We report brain magnetic resonance imaging findings in three infants who had severe
neonatal hyperbilirubinemia, and presented later on with different neurological manifestations.
Two children presented at 6 months of age with global developmental delay, dystonia
and hearing impairment. The third child presented with developmental delay, nystagmus
and superior gaze palsy at ten months of age. The history and clinical picture suggested
sequelae of bilirubin encephalopathy (kernicterus). Magnetic resonance imaging of
the brain in all the patients revealed hyperintensity in bilateral globus pallidus
on T2-weighted images. Increased apparent diffusion coefficient values were observed
in the affected regions on diffusion-weighted imaging, which has not been reported
previously.
Keywords
Neonate - infant - kernicterus - MRI - DWI - ADC values
