PDE4B gene polymorphism in Russian patients with panic disorder

Alena V Malakhova; Olga I Rudko; Vladimir V Sobolev; Artemii V Tretiakov; Elena A Naumova; Zarema G Kokaeva; Julia E Azimova; Eugene A Klimov

doi:10.3934/genet.2019.3.55

AIMS Genetics, Table of Contents

CC BY 4.0 · AIMS Genet 2019; 06(03): 055-063
DOI: 10.3934/genet.2019.3.55

Research Article

PDE4B gene polymorphism in Russian patients with panic disorder

Authors

Alena V Malakhova

¹Lomonosov Moscow State University, Faculty of Biology, Moscow, Russia
Olga I Rudko

¹Lomonosov Moscow State University, Faculty of Biology, Moscow, Russia
Vladimir V Sobolev

²I.I. Mechnikov Research Institute for Vaccines and Sera, Laboratory of molecular immunology, Moscow, Russia

³University Diagnostic Laboratory LLC, Moscow, Russia

⁴Centre of Theoretical Problems of Physico-Chemical Pharmacology, Laboratory of Physicochemical and Genetic Problems of Dermatology, Russian Academy of Sciences, Moscow, Russia
Artemii V Tretiakov

¹Lomonosov Moscow State University, Faculty of Biology, Moscow, Russia
Elena A Naumova

¹Lomonosov Moscow State University, Faculty of Biology, Moscow, Russia
Zarema G Kokaeva

¹Lomonosov Moscow State University, Faculty of Biology, Moscow, Russia
Julia E Azimova

⁵University headache clinic LLC, Moscow, Russia

⁶The Institute of General Pathology and Pathophysiology, Laboratory of Fundamental and Applied Pain Problems, Moscow, Russia
Eugene A Klimov

¹Lomonosov Moscow State University, Faculty of Biology, Moscow, Russia

³University Diagnostic Laboratory LLC, Moscow, Russia

⁷Center of Experimental Embryology and Reproductive Biotechnologies, Russian Academy of Sciences, Moscow, Russia

Abstract

Background Panic disorder is a complex disease of unclear etiology but with an apparent genetic component. PDE4B gene product is involved in many cell processes owing to its function-regulation of the level of a second messenger cAMP. PDE4B gene polymorphism has been shown to be associated with some mental disorders including panic disorder.

Aims The goal of our study was to evaluate the role of 3 SNPs in the PDE4B gene in the development of panic disorder.

Methods 94 patients diagnosed with panic disorder according to the DSM-IV criteria were enrolled in the study. The population control group included 192 subjects. Genotyping was carried out by real-time PCR with TaqMan probes.

Results The investigated substitutions are not associated with panic disorder in general and in female/male cohorts (p > 0.05). The analysis of complex genotypes demonstrated two protective complex genotypes (rs1040716:A, T + rs10454453:A + rs502958:A and rs1040716:A, T + rs502958:A) associated with panic disorder in general regardless of the patient's gender (p < 0.05). These genotypes did not correlate with the patient's sex.

Conclusions We found two complex protective genotypes associated with panic disorder. This can be due to the fact that predisposition to the disease are associated with other genes, while PDE4B gene polymorphism reduces their effect.

Keywords

PDE4B gene - rs10454453 - rs502958 - rs1040716 - panic disorder - genetic association

Full Text

References

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