Clinical applications of functional MRI in epilepsy

Chandrasekharan Kesavadas; Bejoy Thomas

doi:10.4103/0971-3026.41829

Indian Journal of Radiology and Imaging, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2008; 18(03): 210-217
DOI: 10.4103/0971-3026.41829

Neuroradiology

Clinical applications of functional MRI in epilepsy

Authors

Chandrasekharan Kesavadas

Department of Imaging Sciences and Interventional Radiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum - 695 011, India
Bejoy Thomas

Department of Imaging Sciences and Interventional Radiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum - 695 011, India

Abstract

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Abstract

The role of functional MRI (fMRI) in the presurgical evaluation of patients with intractable epilepsy is being increasingly recognized. Real-time fMRI is an easily performable diagnostic technique in the clinical setting. It has become a noninvasive alternative to intraoperative cortical stimulation and the Wada test for eloquent cortex mapping and language lateralization, respectively. Its role in predicting postsurgical memory outcome and in localizing the ictal activity is being recognized. This review article describes the biophysical basis of blood-oxygen-level-dependent (BOLD) fMRI and the methodology adopted, including the design, paradigms, the fMRI setup, and data analysis. Illustrative cases have been discussed, wherein the fMRI results influenced the seizure team′s decisions with regard to diagnosis and therapy. Finally, the special issues involved in fMRI of epilepsy patients and the various challenges of clinical fMRI are detailed.

Keywords

Epilepsy - functional MRI

PDF (288 kb)

Referenzen

References
1 Matthews PM, Jezzard P. Functional magnetic resonance imaging. J Neurol Neurosurg Psychiatry 2004;75:6-12.
2 Roy CS, Sherrington CS. On the regulation of the blood-supply of the brain. J Physiol 1890;11:85-158.
3 Thulborn KR, Waterton JC, Mathews PM, Radha GK. Oxygenation dependence of the transverse relaxation time of water protons in whole blood at high field. Biochim Biophys Acta 1982;714:265-70.
4 Ogawa S, Lee TM, Nayak AS, Glynn P. Oxygeneration sensitive contrast in magnetic resonance image of sodent brain at high magnetic fields. Magn Reson Med 1990;14:68-78.
5 Kwong KK, Belliveau JW, Chesler DA, Goldberg IE, Weisskoff RM, Poncelet BP, et al . Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proc Natl Acad Sci 1992;89:5675-9.
6 Bandettini PA, Wong EC, Hinks RS, Tikofsky RS, Hyde JS. Time course EPI of human brain function during taskactivation. Magn Reson Med 1992;25:390-7.
7 Fration J, Bruhn H, Merboldt KD, Hanicke W, Math D. Dynamic MR imaging of human brain oxygenation during rest and photic stimulation. J Magn Reson Imaing 1992;2:501-5.
8 Ogawa S, Tank DW, Memon R, Ellermann JM, Kim SG, Merkle H, et al . Intrinsic signal charges accompanying sensory stimulation: Functional brain mapping with magnetic resonance imaging. Proc Natl Acad Sci 1992;89:5951-5.
9 Fox PT, Raichle ME. Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects. Proc Natl Acad Sci 1986;83:1140-4.
10 Turner R, Le Bihan D, Moonen CT, Despres D, Frank J. Echo-planar time course MRI of cat brain oxygenation changes. Magn Reson Med 1991;22:159-66.
11 Duong TQ, Kim DS, Ugurbil K, et al . Spatiotemporal dynamics of the BOLD fMRI signals: Toward mapping submillimeter cortical columns using the early negative response. Magn Reson Med 2000;44:231-42.
12 Logothetis NK, Pauls J, Augath M, et al . Neurophysiological investigation of the basis of the fMRI signal. Nature 2001;412:150-7.
13 Mansfield P. Multi-planar image formation using NMR spin echoes. J Phys Chem 1977;10:L55-8.
14 Hoeller M, Krings T, Reinges MH, Hans FJ, Gilsbach JM, Thron A. Movement artefacts and MR BOLD signal increase during different paradigms for mapping the sensorimotor cortex. Acta Neurochir (Wien) 2002;144:279-84.
15 Krings T, Reinges MH, Erberich S, Kemeny S, Rohde V, Spetzger U, et al. Functional MRI for presurgical planning: Problems, artefacts, and solution strategies. J Neurol Neurosurg Psychiatry 2001;70:749-60.
16 Hammeke TA, Yetkin FZ, Mueller WM, Morris GL, Haughton VM, Rao SM, et al. Functional magnetic resonance imaging of somatosensory stimulation. Neurosurgery 1994;35:677-81.
17 Binder JR, Frost JA, Hammeke TA, Cox RW, Rao SM, Prieto T. Human brain language areas identified by functional magnetic resonance imaging. J Neurosci 1997;17:353-62.
18 Kesavadas C, Thomas B, Sujesh S, Ashalata R, Abraham M, Gupta AK, et al. Real-time functional MR imaging (fMRI) for presurgical evaluation of paediatric epilepsy. Pediatr Radiol 2007;37:964-74.
19 Berger MS, Cohen WA, Ojemann GA. Correlation of motor cortex brain mapping data with magnetic resonance imaging. J Neurosurg 1990;72:383-7.
20 Gregorie EM, Goldring S. Localization of function in the -excision of lesions from the sensorimotor region. J Neurosurg 1984;61:1047-54.
21 Jack CR Jr, Thompson RM, Butts RK, Sharbrough FW, Kelly PJ, Hanson DP, et al . Sensory motor cortex: Correlation of presurgical mapping with functional MR imaging and invasive cortical mapping. Radiology 1994;190:85-92.
22 Lehericy S, Duffau H, Cornu P, Capelle L, Pidoux B, Carpentier A, et al . Correspondence between functional magnetic resonance imaging somatotopy and individual brain anatomy of the central region: Comparison with intraoperative stimulation in patients with brain tumors. J Neurosurg 2000;92:589-98.
23 Puce A, Constable RT, Luby ML, McCarthy G, Nobre AC, -Spencer DD, et al . Functional magnetic resonance imaging of sensory and motor cortex: Comparison with electrophysiological localization. J Neurosurg 1995;83:262-70.
24 Yetkin FZ, Mueller WM, Morris GL, McAuliffe TL, Ulmer JL, Cox RW, et al . Functional MR activation correlated with intraoperative cortical mapping. AJNR Am J Neuroradiol 1997;18:1311-5.
25 Lee CC, Ward HA, Sharbrough FW, Meyer FB, Marsh WR, Raffel C, et al . Assessment of functional MR imaging in neurosurgical planning. AJNR Am J Neuroradiol 1999;20:1511-9.
26 Kesavadas C, Thomas B, Sujesh S, Gupta AK. Functional MR Imaging (fMRI) Study of cortical reorganisation in focal cortical dysplasia (FCD) Proceedings of Radiological Society of North America (RSNA) 2007.
27 Adcock JE, Wise RG, Oxbury JM, Oxbury SM, Matthews PM. Quantitative fMRI assessment of the differences in lateralization of language-related brain activation in patients with temporal lobe epilepsy. Neuroimage 2003;18:423-38.
28 Binder JR, Swanson SJ, Hammeke TA, Morris GL, Mueller WM, Fischer M, et al . Haughton determination of language dominance using functional MRI: A comparison with the Wada test. Neurology 1996;46:978-84.
29 Jokeit H, Okujava M, Woermann FG. Memory fMRI lateralizes temporal lobe epilepsy. Neurology 2001;57:1786-93.
30 Detre JA, Maccotta L, King D, Alsop DC, Glosser G, D′Esposito M, et al . Functional MRI lateralization of memory in temporal lobe epilepsy. Neurology 1998;50:926-32.
31 Golby AJ, Poldrack RA, Illes J, Chen D, Desmond JE, Gabrieli JD. Memory lateralization in medial temporal lobe epilepsy assessed by functional MRI. Epilepsia 2002;43:855-63.
32 Rabin ML, Narayan VM, Kimberg DY, Casasanto DJ, Glosser G, Tracy JI, et al . Functional MRI predicts post-surgical memory following temporal lobectomy. Brain 2004;127:2286-98.
33 Powell HW, Richardson MP, Symms MR, Boulby PA, Thompson PJ, Duncan JS, et al . Preoperative fMRI predicts memory decline following anterior temporal lobe resection. J Neurol Neurosurg Psychiatry 2007 Sep 26 [Epub ahead of print] PMID: 17898035.
34 Krakow K, Woermann FG, Symms MR, Allen PJ, Lemieux L, -Barker GJ, et al . EEG-triggered functional MRI of interctal epileptiform activity in patients with partial seizures. Brain 1999;122:1679-88.
35 Lemieux L, Saleek-Haddadi A, Josephs O, Allen P, Toms N, Scott C, et al . Event-related fMRI with simultaneous and continuous EEG: Description of the method and intital case report. Neuroimage 2001;14:780-7.
36 Krakow K, Allen PJ, Symms MR, Lemieux L, Josephs O, Fish DR. EEG recording during fMRI experiments: Image quality. Hum Brain Mapp 2000;10:10-5.
37 Aghakhani Y, Bagshaw AP, Benar CG, Hawco C, Andermann F, Dubeau F, et al . fMRI activation during spike and wave discharges in idiopathic generalized epilepsy. Brain 2004;127:1127-44.
38 Gotman J, Grova C, Bagshaw A, Kobayashi E, Aghakhani Y, Dubeau F. Generalized epileptic discharges show thalamocortical activation and suspension of the default state of the brain. Proc Natl Acad Sci USA 2005;102:15236-40.
39 Zijlmans M, Huiskamp G, Hersevoort M, Seppenwoolde JH, van Huffelen AC, Leijten FS. EEG-fMRI in the preoperative work-up for epilepsy surgery. Brain 2007;130:2343-53.
40 Jokeit H, Okujava M, Woermann FG. Carbamazepine reduces memory induced activation of mesial temporal lobe structures: A pharmacological fMRI-study. BMC Neurol 2001;1:6.
41 Janszky J, Ollech I, Jokeit H, Kontopoulou K, Mertens M, Pohlmann-Eden B, et al . Epileptic activity influences the lateralization of mesiotemporal fMRI activity. Neurology 2004;63:1813-7.
42 Jayakar P, Bernal B, Santiago Medina L, Altman N. False lateralization of language cortex on functional MRI after a cluster of focal seizures. Neurology 2002;58:490-2.
43 Sunaert S, Yousry TA. Clinical applications of functional magnetic resonance imaging. Neuroimaging Clin N Am 2001;11:221-36.
44 Gao JH, Milller I, Lai S, Xiong J, Fox PT. Quantitative assessment of blood inflow effects in functional MRI signals. Magn Reson Med 1996;36:314-9.
45 Le Rumeur E, Allard M, Poiseau E, Jannin P. Role of the mode of sensory stimulation in presurgical brain mapping in which functional magnetic resonance imaging is used. J Neurosurg 2000;93:427-31.