Fever, anemia, and splenomegaly: A rare presentation of splenic angiosarcoma

Mridula Shukla; Somprakash Basu; Vijay K Shukla; Mohan Kumar

doi:10.4103/0971-5851.95148

Indian Journal of Medical and Paediatric Oncology, Table of Contents

CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2011; 32(04): 230-232
DOI: 10.4103/0971-5851.95148

CASE REPORT

Fever, anemia, and splenomegaly: A rare presentation of splenic angiosarcoma

Authors

Mridula Shukla

Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
Somprakash Basu

Department of Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
Vijay K Shukla

Department of Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
Mohan Kumar

Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

Abstract

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Abstract

Splenic angiosarcoma is a rare neoplasm that often remains asymptomatic till the onset of massive intra abdominal bleeding that require emergency splenectomy. We report here a case of 60 year old male who presented with on and off fever and a splenomegaly was found on clinical examination suggesting a lymphoproliferative disorder. A contrast enhanced computerized tomography suggested splenic trauma with intracapsular bleed. A splenectomy was carried out that revealed splenic angiosarcoma. Splenomegaly and fever is a very rare presentation of angiosarcoma. Though rare it should be kept in mind when investigating pyrexia of unknown origin.

Keywords

Angiosarcoma - fever - splenomegaly

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References

References
1 Manouras A, Giannopoulos P, Toufektzian L, Markogiannakis H, Lagoudianakis E, Papadima A, et al. Splenic rupture as the presenting manifestation of primary splenic angiosarcoma in a teenage women: A case report. J Med Case Reports 2008;2:133.
2 Falk S, Krishnan J, Meis JM. Primary angiosarcoma of the spleen. A clinicopathologic study of 40 cases. Am J Surg Pathol 1993;17:959-70.
3 Valbuena JR, Levenback C, Mansfield P, Liu J. Angiosarcoma of the spleen clinically presenting as metastatic ovarian cancer. A case report and review of literature. Ann Diagn Pathol 2005;9:289-92.
4 Neuhauser TS, Derringer GA, Thompson LD, Fanburg-Smith JC, Miettinen M, Saaristo A, et al. Splenic angiosarcoma: A clinicopathologic and immunophenotypic study of 28 cases. Mod Pathol 2000;13:978-87.
5 Sun HY, Zheng M, Liu WL, Zhou JF, Deng JN, Huang M. The clinical application of splenectomy in pyrexia of unknown origin with splenomegaly. Zhonghua Nei Ke Za Zhi 2005;44:89-91.
6 Sordillo EM, Sordillo PP, Hajdu SI. Primary hemangiosarcoma of the spleen: Report of four cases. Med Pediatr Oncol 1981;9:319-24.
7 Michot F, Bruggisser D, Fehr H, Yurtsever H, Anabitarte M. Microangiopathic hemolytic anemia, erythrophagocytosis and consumptioncoagulopathy in vinyl chloride-induced hemangiosarcoma of the spleen and liver. Schweiz Med Wochenschr 1987;117:990-5.
8 Thompson WM, Levy AD, Aguilera NS, Gorospe L, Abbott RM. Angiosarcoma of the spleen: Imaging characteristics in 12 patients. Radiology 2005;235:106-15.
9 Yücel AE, Durak H, Bernay I, Bayraktar Y, Bekdik C, Telatar H. Functional asplenia and portal hypertension in a patient with primary splenic hemangiosarcoma. Clin Nucl Med 1990;15:324-6.
10 Hai SA, Genato R, Gressel I, Khan P. Primary splenic angiosarcoma: Case report and literature review. J Natl Med Assoc 2000;92:143-6.
11 Kinoshita A, Sakon M, Monden M, Gotoh M, Kobayashi K, Okuda H, et al. Triple synchronous malignant tumours-hepatic leiomyosarcoma, splenic angiosarcoma and sigmoid colon cancer: A case report. Acta Chir Scand 1988;154:477-9.