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CC BY-NC-ND 4.0 · J Lab Physicians 2017; 9(03): 214-216
DOI: 10.4103/0974-2727.208253
Case Report

Proximal epithelioid sarcomatous dedifferentiation in secondary chondrosarcoma in a known case of multiple osteochondromatosis

Biswajit Dey
Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India
,
Mangesh Chikhale
Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India
,
Prita Pradhan
Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India
,
Adarsh Barwad
Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India
,
Bhawana Ashok Badhe
Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Osteochondroma is the most common benign bone tumor. Approximately 15% of osteochondromas occur as multiple lesions. Multiple osteochondromatosis has a higher risk of developing chondrosarcomas, which are of low grade with good prognosis. About 10% of all chondrosarcomas may undergo dedifferentiated change, which has a poorer prognosis. Dedifferentiated peripheral chondrosarcoma developing within an osteochondroma is extremely rare. Dedifferentiation usually occurs in the form of osteosarcoma, malignant fibrous histiocytoma, fibrosarcoma, or rhabdomyosarcoma. We report a case of proximal epithelioid sarcomatous dedifferentiation in secondary chondrosarcoma in a 39-year-old male with multiple osteochondromatosis in bilateral arm. To the best of our knowledge, epithelioid sarcomatous dedifferentiation has not been described in the literature.

Key words

Osteochondroma - sarcoma - secondary


Publication History

Received: 05 September 2016

Accepted: 12 December 2016

Article published online:
19 February 2020

© 2017.

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