Abstract
Peroral cholangioscopy (POC) provides direct visualization of the bile duct and facilitates
diagnostic or therapeutic intervention. The currently available single-operator POC
systems are “Mother-baby” scope system, SpyGlass direct visualization system, and
direct POC using a regular ultra-slim upper endoscope. Direct POC using an ultra-slim
upper endoscope having a larger 2-mm working channel can provide a valuable and economic
solution for evaluating bile-duct lesions. Main diagnostic procedures under direct
POC are visual characterization and optically guided target biopsy for the indeterminate
bile duct lesion. Image-enhanced endoscopy such as narrow-band imaging has shown promise
for more detailed evaluation of mucosal abnormality and can be performed under direct
POC. Intracorporeal lithotripsy such as electrohydraulic lithotripsy or laser lithotripsy
is a main therapeutic intervention of direct POC for patients with bile duct stones
that are resistant to conventional endoscopic stone-removal procedures. Besides, tumor
ablation therapy, such as photodynamic therapy and argon plasma coagulation may be
also performed using direct POC. Further developments of the endoscope and specialized
accessories or devices are expected to facilitate diagnostic and therapeutic role
of this cholangioscopic procedure.
Key words
Peroral cholangioscopy - ultra-slim endoscope - spyglass - narrow-band imaging - lithotripsy
- tumor ablation