Abstract
Phase analysis has been validated to measure left ventricular (LV) dyssynchrony from
resting gated SPECT myocardial perfusion imaging (MPI). In 1-day rest/stress protocols,
often only post-stress gated data are acquired. The purpose of this study was to determine
whether LV dyssynchrony parameters measured at post-stress significantly differ from
those measured at rest. Sixty normal subjects, 40 patients with stress-induced ischemia
but normal LV function, and 29 patients with LV dysfunction were included in this
study. All patients were scanned using a 2-day Technetium-99m sestamibi (MIBI) MPI
protocol, where gated SPECT data were acquired at 60 min post injection of the radiotracer.
LV dyssynchrony parameters at post-stress and at rest were calculated and compared
using paired t-test. There were no significant differences in the LV dyssynchrony parameters between
post-stress and resting in all cohorts. No patient showed differences in the LV dyssynchrony
parameters between the post-stress and resting scans significantly greater than the
reported variations in these parameters between serial resting scans. There was no
significant difference in dyssynchrony parameters measured at rest and 60 min after
stress on MPI gated images.
Keywords
Left ventricular dyssynchrony - myocardial perfusion imaging - phase analysis
