Comparison of [15O] H2O positron emission tomography and functional magnetic resonance imaging in activation studies

Masashi Kameyama; Koji Murakami; Masahiro Jinzaki

doi:10.4103/1450-1147.172139

World Journal of Nuclear Medicine, Table of Contents

CC BY-NC-ND 4.0 · World J Nucl Med 2016; 15(01): 3-6
DOI: 10.4103/1450-1147.172139

Review article

Comparison of [¹⁵O] H₂O positron emission tomography and functional magnetic resonance imaging in activation studies

Authors

Masashi Kameyama

¹Division of Nuclear Medicine, National Center for Global Health and Medicine, Tokyo, Japan

²Division of Nuclear Medicine, Keio University, Tokyo, Japan
Koji Murakami

²Division of Nuclear Medicine, Keio University, Tokyo, Japan
Masahiro Jinzaki

³Department of Radiology, School of Medicine, Keio University, Tokyo, Japan

Abstract

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[¹⁵O] H₂O positron emission tomography (PET) has long been out of use in activation studies on the brain. Indeed, it is true that blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) has better spatial resolution and temporal resolution than PET, as well as no radiation exposure. However, PET and fMRI differ in their scope. Compared to fMRI, [¹⁵O] H₂O PET offers advantages such as being quantifiable, less deteriorated by movement, and allowing for longitudinal studies. This article aimed to reassess the merits of PET in this context.

Keywords

Arterial spin labeling - blood oxygen level dependent - cerebral blood flow - magnetic resonance imaging - positron emission tomography

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