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CC BY-NC-ND 4.0 · Ibnosina Journal of Medicine and Biomedical Sciences 2012; 04(03): 78-83
DOI: 10.4103/1947-489X.210760
Article

In vivo antiplasmodial activity of byrsocarpus coccineus leaf extract in mice infected with plasmodium berghei

Joseph Akpan
1   Department of Pharmacology, Faculty of Clinical Medicine, Ebonyi State University, Abakaliki, Nigeria
,
Godwin Akuodor
2   Department of Pharmacology, College of Medical Sciences, University of Calabar, Nigeria
,
B Ezeokpo
1   Department of Pharmacology, Faculty of Clinical Medicine, Ebonyi State University, Abakaliki, Nigeria
,
A Essien
2   Department of Pharmacology, College of Medical Sciences, University of Calabar, Nigeria
,
A Bassey
3   Department of Pharmacology, Faculty of Clinical Medicine, University of Uyo, Nigeria
,
J.O.C Ezeonwumelu
4   School of Pharmacy, Kampala International University, Ishaka Buchenyi, Uganda
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Objective: To investigate the in vivo antiplasmodial activity of ethanolic leaf extract of Byrsocarpus coccineus in mice infected with Plasmodium berghei. Methods: Curative effect against established infection and suppressive activity against early infection were screened. Results: The extract (100,200 and 400 mg/kg, p.o.) has significant (p<0.05) dose dependent activity against the parasites in the curative and suppressive tests. The extract also prolonged the survival time of the infected mice. The oral LD50 values were greater than 5000 mg/kg in mice. Conclusion: The result shows that the extract possesses considerable antiplasmodial activity which can be exploited in malaria therapy.

Key-words:

Byrsocarpus coccineus - Medicinal plant - Antiplasmodial activity - Pasmodium berghei - Mice.


Publication History

Received: 06 October 2011

Accepted: 15 December 2011

Article published online:
23 May 2022

© 2012. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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