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CC BY-NC-ND 4.0 · Avicenna J Med 2016; 06(03): 69-74
DOI: 10.4103/2231-0770.184063
ORIGINAL ARTICLE

CD10 and CD138 can be expressed in giant cell tumor of bone: An immunohistochemical study

Mousa A Al-Abbadi
Department of Pathology and Laboratory Medicine, King Fahad Specialist Hospital, Dammam, Kingdom of Saudi Arabia
,
Mohammed J Al-Yousef
Department of Pathology and Laboratory Medicine, King Fahad Specialist Hospital, Dammam, Kingdom of Saudi Arabia
,
Mohammad M Yousef
Department of Pathology and Laboratory Medicine, King Fahad Specialist Hospital, Dammam, Kingdom of Saudi Arabia
,
Salwa S Sheikh
Department of Pathology and Laboratory Medicine, Johns Hopkins Aramco Healthcare, Dhahran, Kingdom of Saudi Arabia
,
Nidal M Almasri
Department of Pathology and Laboratory Medicine, Saad Specialist Hospital, Al Khobar, Kingdom of Saudi Arabia
,
Samir S Amr
Department of Pathology and Laboratory Medicine, King Fahad Specialist Hospital, Dammam, Kingdom of Saudi Arabia
› Institutsangaben Financial support and sponsorship Department of Pathology and Laboratory Medicine at King Fahad Specialist Hospital, Dammam, Saudi Arabia.
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Abstract

Giant cell tumor of bone (GCTB) is a primary bone neoplasm which is characterized by the presence of mononuclear cells (MCs) and osteoclast-like multinucleated giant cells (MNGCs). Up to our knowledge, CD10 immunoreactivity in GCTB has not yet been studied, and only one study touched on CD138 immunoreactivity in GCTB. The objective of this study is to investigate the immunoreactivity of CD10 and CD138 in GCTB. We offer a discussion of our findings in the context of the differential diagnosis, particularly in small biopsy material. We retrieved and reviewed 15 well-documented cases of GCTB from January 2008 to December 2014. Well-controlled standard immunohistochemical satins were performed on these cases for CD10 and CD138 and few other selected antibodies. Immunoreactivity for CD10 was membranous and was found in 14 (93%) cases. This immunoreactivity was found only in the MCs, whereas the MNGC were all negative. CD138 showed variable positivity in 11 (73%) while 4 (37%) were completely negative. Similar to CD10, staining for CD138 was only seen in the MC; however, the immunoreactivity was predominantly concentrated in the peri-vascular areas. Most of GCTB cases can show variable immunoreactivity for CD10 and CD138. The aforementioned immune-expression raise the possibility of a role in the pathogenesis of GCTB. Paying attention to this immunoreactivity is recommended when considering the clinical and radiological differential diagnosis, especially in small biopsy specimens.

Keywords

CD10 - CD138 - giant cell tumor of bone


Publikationsverlauf

Artikel online veröffentlicht:
09. August 2021

© 2016. Syrian American Medical Society. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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