Abstract
Esthesioneuroblastoma (ENB) is a rare tumor derived from olfactory neuroepithelium.
ENB in a site outside of where olfactory epithelium exists is exceedingly rare with
only five cases of ENB isolated to the sphenoid sinuses described in the literature
to date. To the best of our knowledge, a skin metastasis of ENB outside the head and
neck region has not been reported. We present an unusual case of a 33-year-old male
diagnosed with primary sphenoid sinus ENB, who underwent surgical resection of the
tumor followed by chemoradiation. About 5 months later, the patient developed a dermal
mass in the sternal region, clinically suspicious for metastasis. Fine needle aspiration
(FNA) revealed a tumor with morphological features and immunophenotype consistent
with the metastasis from patient′s known primary sphenoid sinus ENB. Our case demonstrates
that the skin may be a rare site of a metastatic ENB, and FNA is a cost-effective
and reliable diagnostic method of a suspected cutaneous metastasis.
Keywords
Esthesioneuroblastoma - metastasis - skin
