Primary malignant melanoma of the vagina: A case report and review of literature

Abstract

A 60 year old woman presented in gynecology department with bleeding per vagina and subsequently histotpathologically, it was diagnosed as malignant melanoma of the vagina. She underwent excision biopsy. On metastatic work-up, Positron emission tomography (PET) scan proved that she had distant metastasis and received palliative radiotherapy and chemotherapy, with temozolamide. She is alive after one year.

Key words

Malignant melanoma - melanoma - vagina

• References

• 1 Hu DN, Yu GP, McCormick SA. Population based incidence of vulvar and vaginal melanoma in various races and ethnic groups and comparison of other site specific maelanoma. Melanoma Res 2010;20:153-8.
• 2 Fulciniti F, Ascierto PA, Simeone E, Bove P, Lodito S, Russo S, et al. Nevoid melanoma of vagina: Report of one case diagnosed on thin layer cytological preparations. Cytojournal 2007;4:14.
• 3 Piura B, Rabinovich, Yanai-Inber I. A Primary malignant melanoma of vagina: Case report and review of literature. Eur J Gynaecol Oncol 2002;23:195-8.
• 4 Samolis S, Panagopoulos P, Kanellopoullos N, Papastefanou I, Karadaglis S, Katsoulis M. Primary malignant melanoma of vagina: Case report. Eur J Gynaecol Oncol 2010;31;233-4.
• 5 Michael F, Mariano E, Charlotte CS, Pamela TS, Patricea JE, Charles FL, et al. Primary malignant melanoma of vagina. Obstet Gynecol 2010;116:1358-65.
• 6 Tjalma WA, Monagham JM, de Barros Lopes A, Naik R, Nordin A. Primary vaginal melanoma and long term survivors. Eur J Gynaecol Oncol 2001;22:20-2.
• 7 Lin LT, Liu CB, Chen SN, Chiang AJ, Liou WS, Yu KJ. Primry malignant melanoma of the vagina with repeated local recurrences and brain metastasis. J Chin Med Assoc 2011;74:376-9.
• 8 Manlucu ED, Dickson H, Mahmood L, Nath ME. Case 167 - Bloody vaginal discharge, final diagnosis, primary malignant melanoma of vagina (Online). Available from: http://path.upmc.edu/cases/case167/dx.html. [Last accessed on 2012 Jan 28].
• 9 Baloglu A, Bezircioglu I, Cetinkaya B, Yavuzcan A. Promary malignant melanoma of the vagina. Arch Gynecol Obstet 2009;280:819-22.
• 10 Gupta D, Malpica A, Deavers MT, Silva EG. Vaginal melanoma: A clinicopathologic and immunohistochemical study of 26 cases. Am J Surg Pathol 2002;26:1450-7.
• 11 Miner TJ, Delgado R, Zeisler J, Busam K, Alektiar K, Barakat R, et al. Primary vaginal melanoma: A critical analysis of therapy. Ann Surg Oncol 2004;11:34-9.
• 12 McKinnan JG, Kokal WA, Neifeld JP. Natural history and treatment of mucosal melanoma. J Surg Oncol 1989;41:222-5.
• 13 Moros ML, Ferrer FP, Mitchell MJ, Romeo JA, Lacruz RL. Primary malignant melanoma of vagina - poor response to radical surgery and adjuvant therapy. Eur J Obstet Gynecol Reprod Biol 2004;113:248-50.
• 14 Fallahian M, Zare KH. Multifocal malignant melanoma of female genital tract. Iran J Med Sci 2006;31:235-7.
• 15 Petru E, Nagele F, Czerwenka K. Primary malignant melanoma of vagina: Long term remission following radiation therapy. Gynecol Oncol 1998;70:23-6.
• 16 Rosenberg SA, Yang JC, Schwartzentruber DJ, Hwu P, Marincola FM, Topalian SL, et al. Prospective randomized trial of the treatment of patients with metastatic melanoma using chemotherapy with cisplatin, decabazine and tamoxifen alone or in combination with interleukin 2 and interferon alfa - 2b. J Clin Oncol 1999;17:968-75.
• 17 Androutsopoulos G, Adonakis G, Ravazoula P, Kourounis G. Primary malignant melanoma of vagina: A case report. Eur J Gynaecol Oncol 2005;26:661-2.