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CC BY-NC-ND 4.0 · South Asian J Cancer 2013; 02(04): 220-224
DOI: 10.4103/2278-330X.119920
THE WAR ON MICROBES: Original Article

Prognostic factors for mortality with fungal blood stream infections in patients with hematological and non-hematological malignancies

Zena Salih
The Christie NHS Foundation Trust, 550 Wilmslow Road, Manchester, UK
,
Jim Cavet
The Christie NHS Foundation Trust, 550 Wilmslow Road, Manchester, UK
,
Mike Dennis
The Christie NHS Foundation Trust, 550 Wilmslow Road, Manchester, UK
,
Tim Somervaille
The Christie NHS Foundation Trust, 550 Wilmslow Road, Manchester, UK
,
Adrian Bloor
The Christie NHS Foundation Trust, 550 Wilmslow Road, Manchester, UK
,
Samar Kulkarni
The Christie NHS Foundation Trust, 550 Wilmslow Road, Manchester, UK
› Author Affiliations Source of Support: Nill.
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Abstract

Background: This single center retrospective analysis was undertaken to identify the incidence, clinical impact, and prognostic factors for mortality associated with fungal blood stream infections (BSI) in cancer patients. Materials and Methods: One hundred and twenty four patients had 169 episodes of fungal BSI. Incidence has not changed over a 10 year period but non albicans candida species are the predominant fungal isolates. Mortality with fungal BSI was significantly higher than that with other microbial agents. Risk of mortality was associated with renal dysfunction and Candida albicans as the isolate. Type of chemotherapy, patient characteristics, and neutrophil count did not influence the mortality following fungal BSI. Conclusion: Fungal BSI is rare and the incidence has not changed in this hospital. Mortality associated with fungal BSI is high. Risk score at the time of developing fungal BSI has prognostic potential to identify patients with higher risk of mortality associated with fungal BSI.

Key words

Fungal blood stream infections - oncology - hematology


Publication History

Article published online:
31 December 2020

© 2013. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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