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CC BY-NC-ND 4.0 · South Asian J Cancer 2014; 03(01): 057-059
DOI: 10.4103/2278-330X.126527
DRUG REVIEW : Review Article

Eribulin drug review

Nishitha Shetty
Department of Medical Oncology, Tata Memorial Hospital, Parel, Mumbai, Maharashtra
,
Sudeep Gupta
Department of Medical Oncology, Tata Memorial Hospital, Parel, Mumbai, Maharashtra
› Author Affiliations Source of Support: Nill.
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Abstract

Eribulin is an anticancer drug approved for treatment of metastatic breast cancer. This drug is a synthetic derivative from Japanese marine sponge Halichondria okadai. It acts by interfering with the microtubular growth ultimately leading to apoptosis after prolonged mitotic blockage. In patients with metastatic breast cancer refractory to anthracyclines and taxanes, eribulin is one of the life-saving options. Neutropenia, neuropathy and QT prolongation are the most frequent adverse events associated with this drug. Phase I/II trials are also underway in refractory lung, ovarian, pancreatic, bladder, and soft tissue tumors. Larger prospective studies will define the role of this drug in a wide variety of tumors, and the future looks very promising.

Key words

Eribulin - taxane - breast chemotherapy


Publication History

Article published online:
31 December 2020

© 2014. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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