Correlation between maternal copper deficiency and premature rupture of membranes: A case–Control study

Hamdi Nawfal; Ahmad Alhamid; Abd Al-Hamid Abd Al-Jawad; Abdurrahman Waez; Razan Hallak; Sherine Shammou; Somayya Tabsho; Muhammad Mazketly; Muhammad Saadi; Amir Sakur

doi:10.4103/LIUJ.LIUJ_4_20

Libyan International Medical University Journal, Table of Contents

CC BY-NC-ND 4.0 · Libyan International Medical University Journal 2020; 05(02): 32-36
DOI: 10.4103/LIUJ.LIUJ_4_20

Original Article

Correlation between maternal copper deficiency and premature rupture of membranes: A case–Control study

Hamdi Nawfal

Department of Embryology, Faculty of Medicine, University of Aleppo, Aleppo, Syria

,

Ahmad Alhamid

Department of Embryology, Faculty of Medicine, University of Aleppo, Aleppo, Syria

,

Abd Al-Hamid Abd Al-Jawad

Department of Embryology, Faculty of Medicine, University of Aleppo, Aleppo, Syria

,

Abdurrahman Waez

Department of Embryology, Faculty of Medicine, University of Aleppo, Aleppo, Syria

,

Razan Hallak

Department of Embryology, Faculty of Medicine, University of Aleppo, Aleppo, Syria

,

Sherine Shammou

Department of Embryology, Faculty of Medicine, University of Aleppo, Aleppo, Syria

,

Somayya Tabsho

Department of Embryology, Faculty of Medicine, University of Aleppo, Aleppo, Syria

,

Muhammad Mazketly

Department of Embryology, Faculty of Medicine, University of Aleppo, Aleppo, Syria

,

Muhammad Saadi

Department of Embryology, Faculty of Medicine, University of Aleppo, Aleppo, Syria

,

Amir Sakur

¹Analytical and Food Chemistry Department, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria

› Author Affiliations

Abstract

Background: The association between maternal serum copper levels and premature rupture of membranes (PROM) is debated. Aims: This study aims to study the relationship between maternal serum copper levels and the incidence of PROM and to determine risk factors of PROM in Aleppo University Hospital of Obstetrics and Gynecology. Settings and Design: Sixty pregnant women were subjected for this study. Materials and Methods: Pregnant women were subjected for analyzing serum copper concentrations. Maternal serum copper levels were measured by atomic absorption spectroscope. Statistical Analysis: By SPSS (version 22.0). Results: A significant correlation was found between maternal serum copper levels and the incidence of PROM. The relationship presents when copper level is considered as a categorical variable, as mothers with copper deficiency were significantly more vulnerable for PROM (Odds ratios = 0.15, confidence intervals: 0.04–0.61, P = 0.002). Furthermore, the relationship presents when copper level is considered as a numerical variable, as mothers with lower serum copper levels were at significantly higher risk to develop PROM. Difference in means between the two groups was 40.87 μg/dL with CI (14.98–66.75) μg/dL (P = 0.003). Conclusion: Within its limitations, this study suggests a significant relationship between maternal serum copper levels and PROM.

Key-words:

Case control - copper - premature rupture of membranes - Syria

Full Text

References

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