CC BY-NC-ND 4.0 · Avicenna J Med 2018; 8(02): 58-62
DOI: 10.4103/ajm.AJM_135_17

CD4-positive lymphoepithelial-like carcinoma: Report of unusual case

Luaay Aziz
Department of Ent and Head and Neck Surgery, Healthpoint Hospital, Abu Dhabi, United Arab Emirates
Raya Saab
Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon
Toufic Eid
Department of Radiation Oncology, American University of Beirut, Beirut, Lebanon
Mousa A Al-Abbadi
Department of Pathology and Laboratory Medicine, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates
› Author Affiliations
Financial support and sponsorship Nil.


We are reporting an unusual case of lymphoepithelial-like carcinoma (LELC) in an 8-year-old female patient where the tumor cells showed unusual CD4 expression. The lesion was found in the left submandibular neck region, in the vicinity of the submandibular gland. The salivary gland was not infiltrated by the tumor, and the tumor exhibited a classic LELC with single and clusters of tumor cells surrounded by many hematolymphoid cells. The tumor cells revealed strong positivity for Epstein–Bar virus as confirmed by the EBER: Epstein-Barr Virus in situ hybridization (EBER-ISH) method of staining. Interestingly, the tumor cells expressed membranous immunostaining for the T-helper lymphocyte antibody (CD4) in addition to pan-cytokeratin. A brief discussion about this unusual finding is offered. The patient was treated as a case of Epstein–Bar virus-associated nasopharyngeal carcinoma with excellent response.

Publication History

Article published online:
12 August 2021

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