Lympho plasmacytoma is distinct type of diffuse large B cell lymphoma predominantly
seen in HIV-positive patients. The diagnosis of lympho plasmacytoma could be a challenge
due to its overlapping characterizes with those of myeloma and lymphoma. We report
a case of a 50-year-old man who initially presented with a painful solitary destructive
lesion at the second lumbar vertebra. Clinico-pathological findings were consistent
with a solitary plasmacytoma, and he was treated with definitive radiotherapy. Eight
months after completing radiotherapy, he was found to have similar lesions at D4 vertebral
body, multiple ribs, and pelvis. Subsequent biopsy confirmed lympho plasmacytoma.
Because of its rarity and heterogeneous presentations, lympho plasmacytoma could easily
be overlooked clinically and pathologically in immunocompetent patients. The diagnosis
of lympho plasmacytoma should be considered when there is coexpression of myeloma
and lymphoma immune markers.
Key-words:
Lympho plasmacytoma - lymphoma - myeloma - solitary plasmacytoma
