Evaluation of platelet-rich fibrin and platelet-rich plasma in impacted mandibular third molar extraction socket healing and bone regeneration: A split-mouth comparative study

Ravi Bhujbal; Suresh Kandagal Veerabhadrappa; Seema Yadav; Mouneshkumar Chappi; Vinay Patil

doi:10.4103/ejgd.ejgd_133_19

European Journal of General Dentistry, Table of Contents

CC BY-NC-ND 4.0 · European Journal of General Dentistry 2020; 9(02): 96-102
DOI: 10.4103/ejgd.ejgd_133_19

Original Article

Evaluation of platelet-rich fibrin and platelet-rich plasma in impacted mandibular third molar extraction socket healing and bone regeneration: A split-mouth comparative study

Ravi Bhujbal

Department of Oral and Maxillofacial Surgery, Nanded Rural Dental College and Research Center, Nanded, Maharashtra, India

,

Suresh Kandagal Veerabhadrappa

¹Department of Oral Diagnosis and Radiology, Faculty of Dentistry, SEGi University, Petaling Jaya, Selangor, Malaysia

,

Seema Yadav

²Department of Periodontology, Faculty of Dentistry, SEGi University, Petaling Jaya, Selangor, Malaysia

,

Mouneshkumar Chappi

³Department of Oral and Maxillofacial Surgery, School of Dental Sciences, Krishna Institute of Medical Sciences Deemed University, Karad, Maharashtra, India

,

Vinay Patil

Department of Oral and Maxillofacial Surgery, Nanded Rural Dental College and Research Center, Nanded, Maharashtra, India

› Author Affiliations

Abstract

Objective: To compare the efficacy of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) in postoperative extraction socket healing, pain, swelling, and bone regeneration after surgical removal of impacted mandibular third molars. Materials and Methods: The present split-mouth comparative study was conducted on 20 patients undergoing bilateral identical mandibular third molar extraction. PRF was placed on the right side of the third molar extraction socket, and PRP was placed on the contralateral side. Evaluation of soft tissue healing, pain, and swelling was carried out on immediate postoperative and on the 1^st day, 3^rd day, and 7^th day. Radiological bone density was assessed on the 3^rd and 6^th months postoperatively. Results: Soft tissue healing was better in PRF site. The postoperative pain scores in PRF site were less compared with PRP site; however, there was no significant difference between immediate postoperative period (P < 0.15), 1^st day (P < 0.96), 3^rd day (P < 0.58), and 7^th day (P < 0.78). Measurement of swelling on the 1^st day (P < 0.0020) and 3^rd day (P < 0.0010) showed significant difference on PRF site, but it ceases to nonsignificant on the 7^th day (P < 1.00). Postoperative mean bone density at the 3^rd and 6^th months was higher in PRF site, which was statistically significant (P < 0.00001). Conclusion: Our results showed a significant improvement in the soft tissue wound healing and increase in bone density in PRF site than PRP site. There was significant reduction of the swelling found on the 1^st and 3^rd day at PRF site as compared to the PRP site. Although the postoperative pain scores were less in PRF site, this was not statistically significant among the two groups.

Keywords

Pain - platelet-rich fibrin - platelet-rich plasma - soft tissue healing - swelling - third molar

Full Text

References

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