Clinicopathological Features and Treatment Outcomes in Ewing’s Sarcoma Patients: A 10‑year experience of Alexandria Clinical Oncology Department

Asmaa Nazeer; Alaa Kandil; Omar Zahra; Maher Soliman

doi:10.4103/ijmpo.ijmpo_107_17

Indian Journal of Medical and Paediatric Oncology, Table of Contents

CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2017; 38(03): 316-320
DOI: 10.4103/ijmpo.ijmpo_107_17

Original Article

Clinicopathological Features and Treatment Outcomes in Ewing’s Sarcoma Patients: A 10‑year experience of Alexandria Clinical Oncology Department

Authors

Asmaa Nazeer

Department of Oncology, Alexandria Sporting Students' Hospital, Alexandria, Egypt
Alaa Kandil

Department of Oncology, Faculty of Medicine, Alexandria University, Alexandria, Egypt
Omar Zahra

Department of Oncology, Faculty of Medicine, Alexandria University, Alexandria, Egypt
Maher Soliman

Department of Oncology, Faculty of Medicine, Alexandria University, Alexandria, Egypt

Abstract

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Abstract

Background: Ewing's sarcoma (ES) is an aggressive tumor, which is usually associated with micrometastases in the circulation. Thus, systemic chemotherapy in addition to local control modality is essential to improve outcomes. The aim of this study was to evaluate clinicopathological features and treatment outcomes in patients with ES. Materials and Methods: Medical files of 74 patients with nonmetastatic ES treated at our centers between 2004 and 2014 were retrospectively evaluated. The clinicopathological parameters were extracted and statistically correlated with event-free survival (EFS) and overall survival (OS). Results: The median age of patients was 13 years. The median follow-up duration was 63.8 months. About two-thirds (58.1%) of patients were male. Pain (74.3%) was the most common presenting symptom. Extremities (48.6%) were the frequently affected sites. Thirty-two patients (43.2%) presented by tumors larger than 8 cm. All patients were treated with chemotherapy. Local therapies were surgery and/or radiotherapy. The 5-year EFS and OS were 44% and 57%, respectively. On multivariate analysis, EFS and OS were significantly associated with age, tumor site, and tumor size. Conclusions: Despite limited resources in a developing country, the survival rates of ES are comparable to that in developed countries, and prognostic factors are age, tumor site, and tumor size.

Keywords

Chemotherapy - Ewing's sarcoma - prognosis - survival

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References

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