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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2020; 41(03): 418-420
DOI: 10.4103/ijmpo.ijmpo_234_18
Practitioner Section

Priapism in Chronic Myeloid Leukemia: Meeting at the Crossroads and Heading in Different Directions

Kundan Mishra
Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Aditya Jandial
Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Vikram Singh
Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Bishan Das Radotra
Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Pankaj Malhotra
Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Chronic myeloid leukemia (CML) is the most common leukemia presenting with priapism. Due to social stigma or shyness, the real incidence of priapism in our population is difficult to estimate. Since the successful development of tyrosine kinase inhibitors, the life expectancy of CML-chronic phase (CML-CP) has been comparable to the healthy population, and the importance of priapism has further magnified. As of now, the long-term outcome and fertility issues are not very well known. We present the case of a 24-year-old previously healthy gentleman who presented with priapism and was diagnosed as CML-CP. He achieved major molecular response at 18 months. On follow-up at 2 years since the diagnosis, he offers no complaint except moderate erectile dysfunction (International Index of Erectile Function score 11), compromising his quality of life.

Keywords

Chronic myeloid leukemia - erectile dysfunction - imatinib - priapism


Publication History

Received: 28 October 2018

Accepted: 29 September 2019

Article published online:
28 June 2021

© 2020. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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  • References

  • 1 Hinman F. NePriapism; report of cases and a clinical study of the literature with reference to its pathogenesis and surgical treatment. Annonatal. Surg 1914; 60: 689-716
    Google Scholar
  • 2 Schreibman SM, Gee TS, Grabstald H. Management of priapism in patients with chronic granulocytic leukemia. J Urol 1974; 111: 786-8
    CrossrefPubMedGoogle Scholar
  • 3 Warthin AS. Priapism persistent postmortem. Int Clin 1909; 4: 286-92
    Google Scholar
  • 4 Lower WE, Christoferson LA. Priapism in leukemia. Cleveland Clin J Med 1945; 12: 133-7
    CrossrefGoogle Scholar
  • 5 Sahu KK, Mishra K, Dhibar DP, Ram T, Kumar G, Jain S. et al. Priapism as the presenting manifestation of multiple myeloma. Indian J Hematol Blood Transfus 2017; 33: 133-6
    CrossrefPubMedGoogle Scholar
  • 6 Kunst W, Sarin YK. Leukaemisches priapismus mit nervoesen pathogenese. Med Klin 1970; 3: 45-5
    Google Scholar
  • 7 Jandial A, Mishra K, Rajpal S, Kakkar N, Sandal R, Lad D. et al. “Blueberry muffin spots” in an adult male successfully treated with imatinib. Indian J Hematol Blood Transfus 2019; 35: 174-5
    CrossrefPubMedGoogle Scholar
  • 8 Kopp CR, Jandial A, Mishra K, Sandal R, Malhotra P. Myasthenia gravis unmasked by imatinib. Br J Haematol 2019; 184: 321
    CrossrefPubMedGoogle Scholar
  • 9 Sinha S, Lue TF, Hellstrom WJ, McAninch JW, Tanagho EA. A refined approach to diagnosis and treatment. J Urol 1986; 136: 104-8
    CrossrefPubMedGoogle Scholar
  • 10 Chisick L, Seftel M, Kumar R. Algorithm for initial management of priapism in chronic myeloid leukaemia. Br J Haematol 2012; 159: 250-1
    CrossrefPubMedGoogle Scholar
  • 11 Jandial A, Mishra K, Sandal R, Lad D, Prakash G, Khadwal A. et al. CML patients presenting with priapism: Is there any disparity in outcome?. J Clinical Oncology 2019; 37 (15 Suppl): e18545-e18545 DOI: 10.1200/JCO.2019.37.15_suppl.e18545.
    CrossrefGoogle Scholar
  • 12 Sandal R, Jandial A, Mishra K, Prakash G, Khadwal A, Lad D. et al. Outcome of CML patients with de novo bleeding complications: Do they behave differently?. J Clinical Oncology 2019; 37 (Suppl. 15) e18546-e18546 DOI: 10.1200/JCO.2019.37.15_suppl.e18546.
    CrossrefGoogle Scholar