Abstract
Context: The non-Hodgkin's lymphomas (NHLs) are lymphoid neoplasms that arise primarily in
the lymph nodes. They are classified into B-cell, T-cell, and natural killer cell
types and are subtyped on the basis of morphologic and immunohistochemical studies.
T-cell neoplasms are clonal tumors of mature and immature T-cells at various stages
of differentiation. T-cell lymphoma is common in Asia compared to Europe and America.
The pattern and prevalence of T-cell lymphoma in India are, however, different from
that of other Asian countries. Aims: The main aim of this study is to analyze the prevalence and pattern of T-cell NHL
in North East India, as less number of studies have been carried out in this part
of the country. Settings and Design: A 5-year retrospective study (2012–2016) was carried out in our institute, which
is a regional cancer center located in North East India. Materials and Methods: Five-year records of previously diagnosed cases were obtained, and then the hematoxylin-
and eosin-stained sections and the immunohistochemistry slides were reviewed and studied.
Results: A total number of 294 cases of NHL were reviewed in the study period. Seventy-one
cases were found to be of T-cell NHL type which comprised 24% of the total NHL. Peripheral
T-cell lymphoma not-otherwise specified (PTCL-NOS) (62%) was the most common followed
by anaplastic large cell lymphoma (27%). T-lymphoblastic lymphoma (7%) was common
in children and young adults. Conclusion: PTCL-(NOS) was found to be the most common T-cell lymphoma. Treatment of most of
the cases was by chemotherapy using the cyclophosphamide, doxorubicin, vincristine,
and prednisone regimen.
Keywords
Immunohistochemistry - North East India - peripheral T-cell lymphoma - T-cell non-Hodgkin
lymphoma
