Is there a clinical usefulness for radiolabeled somatostatin analogues beyond the consolidated role in NETs?

Vincenzo Cuccurullo; Giuseppe Danilo Di Stasio; Maria Rosaria Prisco; Luigi Mansi

doi:10.4103/ijri.IJRI_431_16

Indian Journal of Radiology and Imaging, Table of Contents

CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2017; 27(04): 509-516
DOI: 10.4103/ijri.IJRI_431_16

Miscellaneous

Is there a clinical usefulness for radiolabeled somatostatin analogues beyond the consolidated role in NETs?

Authors

Vincenzo Cuccurullo

Nuclear Medicine Unit, Department of Clinical and Experimental Medicine, F. Magrassi, A. Lanzara, Seconda Università di Napoli, Napoli, Italy
Giuseppe Danilo Di Stasio

Nuclear Medicine Unit, Department of Clinical and Experimental Medicine, F. Magrassi, A. Lanzara, Seconda Università di Napoli, Napoli, Italy
Maria Rosaria Prisco

Nuclear Medicine Unit, Department of Clinical and Experimental Medicine, F. Magrassi, A. Lanzara, Seconda Università di Napoli, Napoli, Italy
Luigi Mansi

Nuclear Medicine Unit, Department of Clinical and Experimental Medicine, F. Magrassi, A. Lanzara, Seconda Università di Napoli, Napoli, Italy

Abstract

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Abstract

The somatostatin (SS) receptor scintigraphy (SRS), using octreotide radiolabelled with 111In (Ocreoscan©, OCT), is a consolidated diagnostic procedure in patients with neuroendocrine tumors (NET) because of an increased expression of somatostatin receptors (SS-R) on neoplastic cells. Uptake of SS analogues (SSA) can also be due to SS-R expression on nonmalignant cells when activated as lymphocytes, macrophages, fibroblasts, vascular cells. Because of this uptake, clinical indications can be found either in neoplasms not overexpressing SS-R, as nonsmall cell lung cancer, and in active benign diseases. Nevertheless, clinical application of SRS has not found clinical relevance yet. In this paper, we discuss the nononcologic fields of clinical interest in which SRS could play a clinical role such as diagnosis, prognosis, and therapy of benign and chronic diseases such as sarcoidosis, histiocytosis, rheumatoid arthritis, idiopathic pulmonary fibrosis, and Graves' ophthalmopathy.

Keywords

Autoimmune diseases - diagnostic imaging - Graves’ ophthalmopathy - octreotide - osteomalacia - paraneoplastic syndromes - sarcoidosis - somatostatin

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References

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