Autoimmune Polyglandular Syndrome (APS) is characterized by presence of immune dysfunction
of two or more endocrine glands and other non-endocrine organs. Only few cases of
APS III associated with different immunological or genetic disorders have been reported.
We present a 17-year old boy presented with easy fatigability, recurrent abdominal
pain, pallor and language impairment; evaluated to have Autoimmune Thyroiditis, Megaloblastic
Anemia due to vitamin B12 deficiency and Type 1 Diabetes Mellitus; with final diagnosis
as APS IIIB with Immune Thrombocytopenia, leucopenia and Beta Thalessemia trait. The
child requires lifelong monitoring of glandular functions and hormone replacement
therapy for established glandular failure or failures. APS IIIB is as yet known to
occur in middle aged women. It should be suspected in younger ages and diagnosed early
to prevent the complications associated with the chronic endocrine deficiencies.
Keywords
Autoimmune polyglandular syndrome - language impairment - thalassemia
