Correlating the treatment outcome with tumor staging, grading, and various treatment modalities in patients with esthesioneuroblastoma

Shuchita Singh; Lavleen Singh; Richa Ranjan; Manoj Kumar Singh; Alok Thakar; Suresh Chandra Sharma

doi:10.4103/sajc.sajc_273_18

South Asian Journal of Cancer, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · South Asian J Cancer 2019; 08(02): 124-126
DOI: 10.4103/sajc.sajc_273_18

ORIGINAL ARTICLE: Head and Neck Cancers

Correlating the treatment outcome with tumor staging, grading, and various treatment modalities in patients with esthesioneuroblastoma

Autor*innen

Shuchita Singh

Department of Otorhinolaryngology, All India Institute of Medical Sciences, New Delhi
Lavleen Singh

Department of Pathology, All India Institute of Medical Sciences, New Delhi
Richa Ranjan

Department of Pathology, All India Institute of Medical Sciences, New Delhi
Manoj Kumar Singh

Department of Pathology, All India Institute of Medical Sciences, New Delhi
Alok Thakar

Department of Otorhinolaryngology, All India Institute of Medical Sciences, New Delhi
Suresh Chandra Sharma

Department of Otorhinolaryngology, All India Institute of Medical Sciences, New Delhi

Abstract

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Abstract

Objective: Although till date no management protocol for esthesioneuroblastoma (ENB) has been standardized due to tumor rarity, still multimodality approach shows better treatment outcomes as compared to surgery alone. The objective of this study was to analyze the clinicopathological spectrum of ENB and to correlate treatment response with tumor staging, histopathological grading, and various treatment modalities. Materials and Methods: Twenty-one consecutive patients with biopsy-proven ENB were studied and evaluated for response to treatment in the form of complete tumor resolution. Results were analyzed and correlated with stage and grade of tumor and form of therapy received. Results: There was male preponderance (3.2:1) with age ranging between 7 and 63 years (median of 25 years). Survival rates significantly dropped with increasing tumor stage (63.6% in stages A and B vs. 30% in stages C and D) and grade (100% in Grades 1 and 2 vs. 31.25% in Grades 3 and 4). The recurrence rate was 80% in surgery alone group, which came down to 43.7% if surgery was supplemented with other modalities. In cases where multimodality treatment plan was used, endoscopic procedures fared equally as open surgical procedures. Conclusion: Hyam’s grade and Kadish stage are important prognostic indicators of treatment outcome, with survival rates dropping with increasing tumor stage and grade. Multimodality treatment protocols have improved the disease outcome, making endoscopic surgery equivalent to radical surgeries regarding result outcomes and giving other advantages such as better cosmesis, less treatment-related morbidities, decreased hospital stay, and better cost-effectiveness.

Key words

Endoscopic excision - esthesioneuroblastoma - radiotherapy - surgery

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Referenzen

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