18FDG PET-CT in sporadic Creutzfeldt-Jakob disease, correlated with MRI and histology

Nicholas Morley; Monika Hofer; Philip Wilkinson; Kevin Bradley

doi:10.4103/wjnm.wjnm_5_21

World Journal of Nuclear Medicine, Table of Contents

CC BY-NC-ND 4.0 · World J Nucl Med 2021; 20(04): 411-413
DOI: 10.4103/wjnm.wjnm_5_21

Case Report

¹⁸FDG PET-CT in sporadic Creutzfeldt-Jakob disease, correlated with MRI and histology

Authors

Nicholas Morley

Department of Radiology, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
Monika Hofer

¹Department of Neuropathology, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
Philip Wilkinson

²Department of Psychiatry, University of Oxford, Oxford, United Kingdom
Kevin Bradley

Department of Radiology, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom

Abstract

We present a case of sporadic Creutzfeldt–Jakob disease with profoundly abnormal 18fluoro-deoxy-glucose positron emission tomography with computed tomography (FDG PET-CT) at an early stage, and correlate this with the clear findings at magnetic resonance imaging and also postmortem histology. Prion diseases are rare but important causes of cognitive impairment. The role of FDG PET-CT is discussed, along with other investigations such as electroencephalography and cerebro-spinal fluid analyses.

Keywords

Dementia - magnetic resonance imaging - positron emission tomography - prion diseases

Full Text

References

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