Abstract
Introduction: Calabash chalk is a naturally occurring mineral, chiefly composed of fossilized sea
shells. It is prepared from clay and mud mixed with other ingredients, including lead,
arsenic, sand and wood ash. Clay consumption is correlated with pregnancy, and also
to eliminate morning sickness in women. The aim of this study is to evaluate the effects
of calabash chalk on the ovarian function in adult female Wistar rats. Methods: Eighteen (18) adult female Wistar rats. Group A served as the control group, group
B received 40 mg/kg body weight of Non-salted calabash chalk while group C received
40 mg/kg body weight of Salted calabash chalk for 14 days. On day 15, the animals
were sacrificed for histological and biochemical examination. Results: Results showed a significant (P< 0.05) reduction in follicle stimulating hormone
(FSH) levels of the treatment groups when compared with the control group and an increase
in luteinizing hormone (LH) levels of the treatment groups when compared with the
control group. Histological examination of the ovaries showed severe deterioration
of the ovarian follicles, necrosis and follicular atresia. Conclusion: Calabash chalk is toxic to ovarian function. These alterations have been shown to
be the leading cause ofinfertility in female rats. Hence, proper monitoring, education,
and regulation of the product is needed.
Keywords
salted calabash chalk - non-salted calabash chalk - follicle stimulating hormone -
ovaries
