Heparin induced thrombocytopenia

Summary

Heparin induced thrombocytopenia (HIT) is a prothrombotic syndrome initiated by platelet-activating auto-antibodies with potentially devastating complications. Once the diagnosis of HIT is suspected, discontinuation of heparin and treatment with an alternative anticoagulant are mandatory. While established drugs for HIT are no longer available, parenteral factor Xa inhibitors, thrombin inhibitors and perhaps the direct oral anticoagulants provide additional treatment options. The aim of this review was to highlight the current clinical aspects regarding HIT focusing on the role of novel medications.

Zusammenfassung

Die Heparin-induzierte Thrombopenie (HIT) ist eine prothrombotische Erkrankung, die durch thrombozytenaktivierende Autoantikörper hervorgerufen wird und fatale Komplikationen auslösen kann. Bei Verdacht auf eine HIT muss Heparin abgesetzt und ein anderes Antikoagulanz gegeben werden. Es gibt zwar keine ausdrücklichen Arzneimittel gegen HIT mehr, aber parenteral verabreichte Faktor-Xa-Inhibitoren, Thrombinhemmer und möglicherweise direkte orale Antikoagulanzien können weitere Therapieoptionen sein. Diese Übersicht soll die aktuellen klinischen Aspekte von HIT mit Schwerpunkt auf der Rolle der neuen Arzneimittel darlegen.

Keywords

HIT - DOAC

Schlüsselwörter

HIT - DOAC

• References

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